Can Replacing CA125 with HE4 in Risk of Malignancy Indices 1–4 Improve Diagnostic Performance in the Presurgical Assessment of Adnexal Tumors?

Table 12

Comparison of predictive accuracy between classical and modified risk of malignancy indices (RMIs) 1–4 in patients with adnexal masses.

Compared RMI variants	value
	Differentiation of malignant from nonmalignant adnexal tumors			Differentiation of malignant stage I (FIGO) from nonmalignant adnexal tumors
	All patients	Premenopausal	Postmenopausal
mRMI 1 versus RMI 1
mRMI 2 versus RMI 2
mRMI 3 versus RMI 3
mRMI 4 versus RMI 4

Modified RMIs (mRMIs) were obtained by replacing cancer antigen 125 with human epididymis secretory protein 4 in the classical RMIs. Predictive accuracy was expressed in terms of the area under the receiver operating characteristic curve. We obtained values using the Hanley and McNeil method.