Can Replacing CA125 with HE4 in Risk of Malignancy Indices 1–4 Improve Diagnostic Performance in the Presurgical Assessment of Adnexal Tumors?

Table 5

Descriptive statistics regarding the distribution of CA125 and HE4 levels in patients with adnexal mass.

Tumor marker	Parameter	Nonmalignant	Malignant
HE4, pmol/L	Mean	53.43	1133.56
	Median	46.55	373.40
	Minimum	17.80	38.30
	Maximum	192.30	8847.00
CA125, U/mL	Mean	41.22	743.63
	Median	20.50	282.40
	Minimum	4.34	6.32
	Maximum	506.80	9083.00

The serum levels of HE4 and CA125 were significantly higher among patients with malignant adnexal masses (p < 0.001). HE4, human epididymis secretory protein 4; CA125, cancer antigen 125