Can Replacing CA125 with HE4 in Risk of Malignancy Indices 1–4 Improve Diagnostic Performance in the Presurgical Assessment of Adnexal Tumors?
Table 8
Diagnostic odds ratio (DOR) and area under the curve (AUC) for the predictive accuracy of classical and modified risk of malignancy indices (RMIs) 1–4 in patients with adnexal mass.
RMI variant
All patients
Premenopausal patients
Postmenopausal patients
DOR (95% CI)
AUC (95% CI)
value
Optimal cut-off
DOR (95% CI)
AUC (95% CI)
value
Optimal cut-off
DOR (95% CI)
AUC (95% CI)
value
Optimal cut-off
RMI 1
62 (26.3–145.6)
0.899 (0.838–0.960)
<0.001
56
24.7 (5.8–104.2)
0.818 (0.654–0.982)
<0.001
19
56.6 (17.6–181.6)
0.906 (0.838–0.973)
<0.001
112
RMI 2
25.9 (12–55.7)
0.900 (0.840–0.960)
<0.001
123
14.4 (3.9–53.4)
0.798 (0.606–0.99)
0.001
59
18.7 (6.8–51.8)
0.895 (0.822–0.969)
<0.001
245
RMI 3
37.7 (17.2–82.7)
0.895 (0.832–0.957)
<0.001
107
15.6 (4.2–58.3)
0.795 (0.604–0.986)
0.001
58
41.2 (13.8–123.3)
0.896 (0.823–0.970)
<0.001
168
RMI 4
35.8 (16.5–77.8)
0.908 (0.851–0.966)
<0.001
219
14.4 (3.7–55.4)
0.802 (0.604–1.000)
0.001
110
32 (11.2–91.6)
0.906 (0.842–0.971)
<0.001
315
mRMI 1
31.1 (13.6–71.2)
0.903 (0.844–0.963)
<0.001
103.2
6.9 (1.7–27.2)
0.839 (0.676–1.000)
<0.001
40
31.1 (10.7–90)
0.907 (0.841–0.973)
<0.001
330
mRMI 2
30.2 (13.2–69)
0.929 (0.886–0.972)
<0.001
250
20.5 (4.2–99.7)
0.875 (0.747–1.000)
<0.001
69
31.1 (10.7–90)
0.923 (0.869–0.978)
<0.001
770
mRMI 3
30.2 (13.2–69)
0.930 (0.887–0.973)
<0.001
188
20.5 (4.2–99.7)
0.876 (0.748–1.000)
<0.001
69
34.4 (11.7–101.1)
0.924 (0.870–0.979)
<0.001
480
mRMI 4
41.3 (17.2–98.8)
0.931 (0.887–0.976)
<0.001
380
19.8 (4.1–96.0)
0.856 (0.707–1.000)
<0.001
118
23.5 (8.5–64.5)
0.930 (0.883–0.977)
<0.001
1300
Modified RMIs (mRMIs) were obtained by replacing cancer antigen 125 with human epididymis secretory protein 4 in the classical RMI. Data are shown with 95% confidence intervals (CIs).
