Quantitative Serum Proteomic Analysis of Essential Hypertension Using iTRAQ Technique

Table 2

Molecular functions, biological processes, and expression levels of 24 differentially expressed proteins.

Protein ID	Protein name	Molecular function	Biological process	A/B
sp|P08311	Cathepsin G	Binding; Catalytic activity	Proteolysis; Regulation of immune response	0.7645
tr|G3XAP6	Cartilage oligomeric matrix protein	Binding; Structural molecule activity	Cell adhesion	1.265
tr|Q0QET7	Glyceraldehyde-3-phosphate dehydrogenase	Binding; Catalytic activity	Oxidation-reduction process	0.842
sp|P05164-2	Myeloperoxidase	Antioxidant activity; Binding; Catalytic activity	Hydrogen peroxide catabolic process; Oxidation-reduction process	0.6755
sp|P01137	Transforming growth factor beta-1	Binding	Epidermal growth factor receptor signaling pathway	0.7945
tr|B3KUI5	Hyaluronidase	Binding; Catalytic activity; Receptor activity	Hyaluronan biosynthetic process; Positive regulation of hyaluronan cable assembly; Response to reactive oxygen species	0.8355
tr|D3DQH8	Secreted protein	Binding	Response to glucocorticoid stimulus; Response to calcium ion	0.7905
tr|A8MUB1	Tubulin alpha-4A	Binding; Catalytic activity; Structural molecule activity	Protein polymerization; Platelet degranulation; Platelet activation	0.8095
tr|J3KQA0	Synaptotagmin I	Binding; Transporter activity	Detection of calcium ion; Glutamate secretion	0.7595
sp|P61626	Lysozyme C	Catalytic activity	Inflammatory	1.213
tr|D3DNU8	Kininogen-1	Binding; Enzyme regulator activity	Elevation of cytosolic calcium ion; Positive regulation of renal sodium excretion; smooth muscle contraction; vasodilation; inflammatory response	1.2835
sp|P02790	Hemopexin	Binding; Transporter activity	Cellular iron ion homeostasis; positive regulation of humoral immune response mediated by circulating immunoglobulin	1.864
sp|P25705-2	ATP synthase subunit alpha	Binding; Catalytic activity; Transporter activity	ADP biosynthetic process; ATP catabolism; Negative regulation of endothelial cell proliferation	0.847
sp|P17600-2	Synapsin-1	Binding; Catalytic activity; Transporter activity	Neurotransmitter secretion	0.7225
tr|M0R116	Sodium/potassium-transporting ATPase subunit	Binding; Catalytic activity; Transporter activity	ATP biosynthetic process; Transmembrane transport	0.807
sp|Q8NBP7	Proprotein convertase subtilisin/kexin type 9	Binding; Catalytic activity; Channel regulator activity	Proteolysis; Negative regulation of catalytic activity; Negative regulation of receptor recycling	0.8745
tr|B4DNK4	Pyruvate kinase	Binding; Catalytic activity	Small molecule metabolic process; Glycolysis	0.816
tr|H0YJ31	Fibulin-5	Binding; Molecular transducer activity; Receptor activity	Regulation of removal of superoxide radicals	0.774
sp|P00738	Haptoglobin	Binding; Catalytic activity	Negative regulation of hydrogen peroxide catabolic process; proteolysis; negative regulation of oxidoreductase activity	1.3475
sp|P08603	Complement factor H	—	Regulation of complement activation	0.7905
tr|B3KUE5	Phospholipid transfer protein	Binding	Vitamin E biosynthetic process	0.7085
sp|P08294	Extracellular superoxide dismutase	Antioxidant activity; Binding; Catalytic activity	Removal of superoxide radicals	0.8715
sp|P02745|	Complement C1q subcomponent subunit A	Binding	Cell-cell signaling; Complement activation, classical pathway	1.5315
tr|B2R5G8|	Serum amyloid A protein	—	Acute-phase response	0.603