Hepatic Immune Microenvironment in Alcoholic and Nonalcoholic Liver Disease

Figure 2

Chronic alcohol consumption impairs the functional properties of both innate and adaptive immune cells in the liver. Chronic alcohol intake results in the activation of innate immunity components, such as KCs/macrophages, and the inhibition of innate immunity components, such as NK and NKT cells, contributing to the pathogenesis of ALD. Moreover, adaptive immunity including T cells and B cells is altered by alcohol consumption, leading to the progression of ALD.