NOTCH1 Mutations in Aortic Stenosis: Association with Osteoprotegerin/RANK/RANKL
Table 2
Clinical characteristics of patients with aortic stenosis and control group for analysis of the circulating biomarkers.
Patients with M ± SD
Patients with BAV M ± SD
Patients with TAV M ± SD
Control group for circulating biomarkers
versus control group
()
()
()
()
Age, years
0.81
Gender, m : f
1.3 : 1
1.8 : 1
1 : 1
1 : 1
0.68
BMI, kg/m2
<0.01
Arterial hypertension, (%)
50 (82)
22 (71)
28 (93)
10 (31)
<0.01
Systolic BP, mmHg
0.26
Diastolic BP, mmHg
0.14
Total cholesterol, mmol/l
0.84
HDL-C, mmol/l
0.33
LDL-C, mmol/l
0.89
Triglycerides, mmol/l
0.54
OPG (pmol/l)
<0.01
sRANKL (pmol/l)
0.06
ОPG/sRANKL
0.3
HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; BMI: body mass index; BP: blood pressure. Patients with AS; value versus control group; value versus control group.
