Investigation into Hypoglycemic, Antihyperlipidemic, and Renoprotective Potentials of Dennettia tripetala (Pepper Fruit) Seed in a Rat Model of Diabetes

Table 1

Hypoglycemic (acute) effect of crude methanol seed extract and fraction (CMEDT and MFDT) in streptozotocin-induced diabetic rats.

Group	Treatment (twice daily)	Plasma glucose concentration (mg/dl)				% reduction
		0 hours	2 hours	4 hours	8 hours
A	CMEDT; 50 mg/kg body weight					47.37
B	CMEDT; 100 mg/kg body weight					−2.76
C	MFDT; 50 mg/kg body weight					28.72
D	MFDT; 100 mg/kg body weight					10.39
E	Glibenclamide 10 mg/kg body weight (positive control)					33.70
F	Negative (untreated) control					−42.63
G	Normal control					16.15

Values are mean ± SEM; ; % reduction in plasma glucose level as compared to zero hours after 8 hours.