Investigation into Hypoglycemic, Antihyperlipidemic, and Renoprotective Potentials of Dennettia tripetala (Pepper Fruit) Seed in a Rat Model of Diabetes

Table 3

Antihyperlipidemic effect of crude methanol seed extract and fraction (CMEDT and MFDT) in streptozotocin-induced diabetic rats.

Group	Treatment (twice daily)	Changes in serum lipid profile in mg/dl
		T. chol.	TG	HDL	LDL	VLDL
A	CMEDT; 50 mg/kg body weight	↓	↓			↓
B	CMEDT; 100 mg/kg body weight			↑
C	MFDT; 50 mg/kg body weight		↓			↓
D	MFDT; 100 mg/kg body weight		↓	↑	↓	↓
E	Glibenclamide 10 mg/kg body weight (positive control)	↓	↓	↑	↓	↓
F	Negative (untreated) control	↑	↑	↑	↑	↑
G	Normal control
-ratio		7.374	5.303	7.595	9.705	5.303
value		0.000	0.001	0.000	0.000	0.001

Values are mean ± SEM; ; when compared with normal control; when compared with negative (untreated) control. ↓ and ↑: decrease and increase.