Investigation into Hypoglycemic, Antihyperlipidemic, and Renoprotective Potentials of Dennettia tripetala (Pepper Fruit) Seed in a Rat Model of Diabetes

Table 5

Effect of crude methanol seed extract and fraction (CMEDT and MFDT) on kidney function parameters in streptozotocin-induced diabetic rats.

Group	Treatment (twice daily)	Changes in serum urea/creatinine
		Urea (mg/dl)	Creatinine (µmol//l)
A	CMEDT; 50 mg/kg body weight		↓
B	CMEDT 100 mg/kg body weight		↓
C	MFDT 50 mg/kg body weight
D	MFDT 100 mg/kg body weight	↑	↓
E	Glibenclamide 10 mg/kg body weight (positive control)	↑	↓
F	Negative (untreated) control	↑	↓
G	Normal control
-ratio		44.732	5.868
value		0.000	0.000

Values are mean ± SEM; ; when compared with normal control; when compared with negative (untreated) control. ↓ and ↑: decrease and increase.