Fabrication and Evaluation of Electrospun, 3D-Bioplotted, and Combination of Electrospun/3D-Bioplotted Scaffolds for Tissue Engineering Applications

Figure 5

Implantation technique of 3D-bioplotted, electrospun, and combined 3D-bioplotted/electrospun scaffolds into a cadaveric porcine knee. (a) A power reamer was used to create an osteochondral defect to a depth of 8 mm and 8 mm diameter. (b) The COR system was used to implant the scaffolds into the osteochondral defect. (c) View of 3D-bioplotted scaffold (left) and electrospun scaffold (right) after implantation. (d) Combined 3D-bioplotted/electrospun scaffold prior to implantation (black arrows indicate electrospun layer, scale bar = 1 mm). (e) Combined 3D-bioplotted/electrospun scaffold inserted into the COR system for implantation (bracket and arrow pointing at scaffold inside the device). (f) Combined 3D-bioplotted/electrospun scaffold after implantation.

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