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BioMed Research International
Volume 2017, Article ID 7073401, 12 pages
Review Article

The Impact of Volatile Anesthetic Choice on Postoperative Outcomes of Cardiac Surgery: A Meta-Analysis

1Faculty of Health, Universidad del Valle, School of Medicine, Hospital Universitario del Valle, Cali, Colombia
2Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Hospital, Baltimore, MD, USA
3Faculty of Health Sciences, Pontificia Universidad Javeriana, Cali, Colombia
4Faculty of Health, Universidad Libre, Cali, Colombia

Correspondence should be addressed to Andres Zorrilla-Vaca; oc.ude.ellavinuoerroc@allirroz.serdna

Received 22 March 2017; Revised 18 June 2017; Accepted 2 July 2017; Published 29 August 2017

Academic Editor: Detlef Obal

Copyright © 2017 Andres Zorrilla-Vaca et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objectives. To evaluate the impact of volatile anesthetic choice on clinically relevant outcomes of patients undergoing cardiac surgery. Methods. Major databases were systematically searched for randomized controlled trials (RCTs) comparing volatile anesthetics (isoflurane versus sevoflurane) in cardiac surgery. Study-level characteristics, intraoperative events, and postoperative outcomes were extracted from the articles. Results. Sixteen RCTs involving 961 patients were included in this meta-analysis. There were no significant differences between both anesthetics in terms of intensive care unit length of stay (SMD −0.07, 95% CI −0.38 to 0.24, ), hospital length of stay (SMD 0.06, 95% CI −0.33 to 0.45, ), time to extubation (SMD 0.29, 95% CI −0.08 to 0.65, ), S100 (at the end of surgery: SMD 0.08, 95% CI −0.33 to 0.49, ; 24 hours after surgery: SMD 0.21, 95% CI −0.23 to 0.65, ), or troponin (at the end of surgery: SMD −1.13, 95% CI −2.39 to 0.13, ; 24 hours after surgery: SMD 0.74, 95% CI −0.15 to 1.62, ). CK-MB was shown to be significantly increased when using isoflurane instead of sevoflurane (SMD 2.16, 95% CI 0.57 to 3.74, ). Conclusions. The volatile anesthetic choice has no significant impact on postoperative outcomes of patients undergoing cardiac surgery.