Opioid Addiction: Social Problems Associated and Implications of Both Current and Possible Future Treatments, including Polymeric Therapeutics for Giving Up the Habit of Opioid Consumption

Table 2

Examples of other alternatives for naltrexone treatments.

Publication Date	Polymer	System	Elaboration method	Release time	Reference
2002	Polyethylene glycol-graft-methyl methacrylate crosslinked	Nanoparticles	Copolymerization	30 days	[17]
2003	Poly(L-lactide)	Matrix devices	Compression-molding of microspheres	75 days	[18]
2003	Poly(L-lactide)	Microspheres	Emulsion solvent evaporation	1 month	[18]
2004	Poly(L-lactide)	Implant	—	1 month	[19]
2006	Polylactide-co-glycolide	Microspheres	O/W emulsion solvent evaporation	1 month	[20]
2006	Poly(L-lactide)	Microspheres	emulsion solvent evaporation	28 days	[21]
2006	Poly(L-lactide)	Matrix devices	Compression of microspheres	360 days	[21]
2009	Bend of poly(N-isopropylacrylamide-acrylamide-vinylpyrrolidone) and PLGA	Nanoparticles	O/W emulsion solvent evaporation	30 days	[22]
2011	Poly (D,L-lactide-co-glycolide)	Microspheres	O/W emulsion solvent evaporation	Up to 25 days	[23]
2012	—	Implant	—	60 days	[24]
2014	Poly [La-(Glc-Leu)] copolymer	Microspheres	O/W emulsion solvent evaporation	28 days	[25]
2014	Poly lactide-co-glycolide	Microspheres	O/W emulsion solvent evaporation	28 days	[26]