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BioMed Research International
Volume 2017, Article ID 7141296, 8 pages
Research Article

Effects of rhBMP-2 Loaded Titanium Reinforced Collagen Membranes on Horizontal Bone Augmentation in Dogs

1Department of Prosthodontics, Korea University Guro Hospital, Seoul, Republic of Korea
2Graduate School of Clinical Dentistry, Korea University, Seoul, Republic of Korea

Correspondence should be addressed to Jeong-Yol Lee;

Received 30 June 2017; Revised 31 August 2017; Accepted 10 September 2017; Published 17 October 2017

Academic Editor: Dong-Wook Han

Copyright © 2017 Ki-Sun Lee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aim of this study was to evaluate the efficacy of growth factor loaded collagen membranes on new bone formation during horizontal bone augmentation. Mandibular defects (4 × 4 × 4 mm) were surgically prepared in six male beagle dogs, which were then protected with one of three types of membranes: (1) titanium mesh, (2) titanium reinforced collagen, or (3) rhBMP-2 loaded titanium reinforced collagen. Animals were euthanized 8 and 16 weeks after surgery, and nondecalcified specimens were prepared and histomorphologically investigated to determine the degree of osteogenesis. Data were analyzed with Friedman test. With respect to the degree of osteogenesis at earlier stage (8 weeks after surgery), there was significantly higher new bone ratio in rhBMP-2 loaded membrane group (). However, with respect to the long-term results (16 weeks after surgery), there were no significant differences among the three membranes (). Based on histomorphometric analysis, there were no significant differences in horizontal bone gaining ratio ().