Research Article
Gastrointestinal Bleeding Is an Independent Risk Factor for Poor Prognosis in GIST Patients
Table 3
Univariate and multivariate analysis for prognostic factors of patients with GI bleeding.
| | Parameters | Median recurrence (days) | Univariate analysis (Kaplan-Meier) | Multivariate analysis hazard ratio (95% CI) |
(Cox-regression) |
| | Gender (female/male) | 1563/1815 | 0.883 | | | | Age (>60/⩽60) | 1797/1658 | 0.889 | | | | Tumor site (gastric/nongastric) | 1760/1706 | 0.914 | | | | Tumor size (>5/⩽5) | 1425/2076 | <0.001 | 1.864 (0.525–6.622) | | | T stage (T2/T3/T4) | 2082/1503/1164 | <0.001 | 1.277 (0.618–2.638) | | | M stage (M0/M1) | 1820/683 | 0.013 | 1.004 (0.103–9.763) | | | Bleeding (positive/negative) | 1366/1999 | <0.001 | 2.332 (1.105–4.919) | 0.026 | | R0 resection (yes/no) | 1872/711 | 0.004 | 0.649 (0.083–5.043) | | | Mitotic index per 50 HPF (<5/≥5) | 1700/1650 | 0.154 | | | | CD117 (positive/negative) | 1685/1452 | 0.799 | | | | CD34 (positive/negative) | 1697/919 | 0.130 | | | | DOG1 (positive/negative) | 1660/760 | 0.090 | | | | Targeted therapy (yes/no) | 1649/1937 | 0.071 | | |
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-value is statistically significant; gastrointestinal hemorrhage is an independent risk factor.
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