Synaptic Reorganization of the Perisomatic Inhibitory Network in Hippocampi of Temporal Lobe Epileptic Patients

Figure 5

Light micrographs show the distribution of CB1-immunopositive fibers in the human control (a) and epileptic (b-c) CA3 regions. (a) Homogeneous CB1-immunopositive meshwork was present around the pyramidal cells. (b) In epileptic patients without hippocampal sclerosis the density of CB1-positive fibers has been increased moderately. (c) Further increase in density has been observed in the CA3 region of the sclerotic hippocampi, if pyramidal cells were preserved. Arrows point to pyramidal cell bodies surrounded by basket-like formations of CB1-positive fibers. Scale bar: 20 μm.

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