Synaptic Reorganization of the Perisomatic Inhibitory Network in Hippocampi of Temporal Lobe Epileptic Patients

Figure 6

Light micrographs show the distribution of CB1-immunopositive fibers in the human control (a) and epileptic (b-c) CA1 regions. (a) CB1-immunopositive axonal network was present in the stratum pyramidale. (b) In epileptic patients without hippocampal sclerosis the density of CB1-positive fibers has been slightly increased. (c) The density of CB1-positive axons has been decreased in the sclerotic CA1 region. Arrows point to pyramidal cell bodies surrounded by basket-like formations of CB1-positive fibers. Arrowheads show axons. Scale bar: 25 μm.

(a)

(b)

(c)