Review Article

Synaptic Reorganization of the Perisomatic Inhibitory Network in Hippocampi of Temporal Lobe Epileptic Patients

Table 1

Distribution of the target elements of PV-positive terminals (%). Changes in the target elements of PV-positive terminals were determined in human control and epileptic dentate gyrus and CA1 region by examining 42 to 107 boutons per patient per region. Percentages were formed for each control subject and epileptic patient and were then averaged. Note that relatively high ratio of PV-positive boutons terminated on other cellular compartments compared to the perisomatic region (i.e., large numbers of terminals gave synapses to dendrites and spines).

ā€‰ā€‰ Number of boutons examined (number of subjects or patients)Soma
(%)
Dendrite (%)Axon initial segment
(%)
Spine
(%)

DGControl105 (2)
Epileptic213 (4)

CA1 regionControl215 (4)
Epileptic275 (4)