Research Article

PEDF Is Associated with the Termination of Chondrocyte Phenotype and Catabolism of Cartilage Tissue

Table 1

Most differentially expressed genes in PEDF-stimulated cells versus nonstimulated control cells (change > 3-fold).

Gene symbolDescriptionFold change Adj p

SAA1Serum amyloid A134.58<1.0
NOS2Nitric oxide synthase 2, inducible20.13
LCN2Lipocalin 215.97<1.0
C3Complement component 312.00
MMP13Matrix metallopeptidase 13 (collagenase 3)10.46
MT1HMetallothionein 1H10.39
HSD11B1Hydroxysteroid (11-beta) dehydrogenase 110.02
LTFLactotransferrin8.94
PTX3Pentraxin 3, long8.92
CXCL5Chemokine (C-X-C motif) ligand 58.86
VNN2Vanin 28.33
BIRC3Baculoviral IAP repeat containing 37.73
CXCL2Chemokine (C-X-C motif) ligand 27.33
MT1FMetallothionein 1F7.25
SOD2Superoxide dismutase 2, mitochondrial7.06
PI3Peptidase inhibitor 3, skin-derived6.82
MT1GMetallothionein 1G6.75
CCL2Chemokine (C-C motif) ligand 26.50
IL32Interleukin 325.85
VCAM1Vascular cell adhesion molecule 15.61
IL4I1Interleukin 4 induced 15.49
LAMB3Laminin, beta 35.46
CX3CL1Chemokine (C-X3-C motif) ligand 15.43
TNFAIP2Tumor necrosis factor, alpha-induced protein 25.31
TLR2Toll-like receptor 24.99
CST2Cystatin SA4.62
CHI3L2Chitinase 3-like 24.44
SLC7A2Solute carrier family 7 (cationic amino acid transporter), member 24.37
RELBV-rel avian reticuloendotheliosis viral oncogene homolog B4.05
IL34Interleukin 343.86
CSF1Colony stimulating factor 1 (macrophage)3.82
TNFAIP8Tumor necrosis factor, alpha-induced protein 83.77
WTAPWilms tumor 1 associated protein3.71
VNN3Vanin 33.66
ELF3E74-like factor 3 (ETS domain transcription factor, epithelial-specific)3.60
RARRES1Retinoic acid receptor responder (tazarotene induced) 13.56
NFKBIANuclear factor of kappa light polypeptide gene enhancer inhibitor, alpha3.53
MMP1Matrix metallopeptidase 1 (interstitial collagenase)3.50
NOD2Nucleotide-binding oligomerization domain containing 23.45
LBPLipopolysaccharide binding protein3.29
LIFLeukemia inhibitory factor3.25
CD74CD74 molecule, major histocompatibility complex, class II invariant chain3.13
TNFAIP3Tumor necrosis factor, alpha-induced protein 33.13
MT1EMetallothionein 1E3.09
IRAK2Interleukin-1 receptor-associated kinase 23.07
MSCMasculine3.06
PLK2Polo-like kinase 23.05
SLC30A2Solute carrier family 30 (zinc transporter), member 23.04
G0S2G0/G1switch 23.00
OGNOsteoglycin
COMPCartilage oligomeric matrix protein
ACTC1Actin, alpha, cardiac muscle 1
CFHComplement factor H
COL9A3Collagen, type IX, alpha 3
COL9A2Collagen, type IX, alpha 2
SLC14A1Solute carrier family 14 (urea transporter)
ADAMTSL2ADAMTS-like 2
CHADChondroadherin
COL2A1Collagen, type II, alpha 1
CYTL1Cytokine-like 1
GDF10Growth differentiation factor 10