PEDF Is Associated with the Termination of Chondrocyte Phenotype and Catabolism of Cartilage Tissue

Table 2

Selected genes with roles in the skeletal system significantly up- or downregulated by rhPEDF.

gene symbol	Description	Fold change	Adj p	Ranking among the upregulated genes	qRT-PCR
					Fold change mean (95% CI)	P value
SAA1	Serum amyloid A1	34.53	<1.0	1	32.5 (11.5–53.5)	0.003
NOS2	Nitric oxide synthase 2, inducible	20.11		2
MMP13	Matrix metallopeptidase 13	10.41		5	7.8 (4.3–11.3)	0.001
SOD2	Superoxide dismutase 2, mitochondrial	7.06		15
TLR2	Toll-like receptor 2	4.99		25
MMP1	Matrix metallopeptidase 1	3.50		38	4.2 (0.2–8.2)	0.03
MMP3	Matrix metallopeptidase 3	2.28		87	7.5 (3.2–11.7)	0.003
PPARG	Peroxisome proliferator-activated receptor gamma	1.65		275
ADAMTS1	ADAM metallopeptidase with thrombospondin type 1 motif, 1	1.55		338
NFKB1	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	1.53		345
IL6	Interleukin 6 (interferon, beta 2)	1.47		386	20.2 (–48.2)	0.04
SOX9	SRY (sex determining region Y)-box 9			370	−(1.2–1.8)	0.001
SOX5	SRY (sex determining region Y)-box 5			143	−(1.2–5.5)	0.01
ACAN	Aggrecan			104	−(1.7–3.2)	0.00006
COL9A1	Collagen, type IX, alpha 1			84
NKX3-2	NK3 homeobox 2			66	−2.2 −(1.7–3.0)	0.00004
FGFR3	Fibroblast growth factor receptor 3			53
S100A1	S100 calcium binding protein A1			41
PRG4	Proteoglycan 4			29
LECT1	Leukocyte cell derived chemotaxin 1			26	−(1.6–18.5)	0.001
COL11A1	Collagen, type XI, alpha 1			25
COL11A2	Collagen, type XI, alpha 2			20
FRZB	Frizzled-related protein			14
COMP	Cartilage oligomeric matrix protein			11	−(3.2–9.2)	0.00001
COL9A2	Collagen, type IX, alpha 2			7
COL9A3	Collagen, type IX, alpha 3			8
CHAD	Chondroadherin			4
COL2A1	Collagen, type II, alpha 1			3	−(3.8–41.4)	0.00001