Zoledronic Acid Regulates Autophagy and Induces Apoptosis in Colon Cancer Cell Line CT26
The cells were exposed to the 200 MZOL and at 12 h, 24 h, 36 h, and 48 h of exposure, the cell fractions were prepared and analyzed by 15% SDS-PAGE followed by Western blotting. (a and c) The level of c-caspase-3 in CT26 cells after being exposed to ZOL. (b and d) The level of p-p53 in CT26 cells after being exposed to ZOL. The data shown in C and D are the mean ± SD of the results of three independent experiments, respectively ( represents significant differences between the experimental and untreated control values).
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