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BioMed Research International
Volume 2017, Article ID 7234528, 7 pages
https://doi.org/10.1155/2017/7234528
Review Article

Association between Serum Homocysteine Level and Obstructive Sleep Apnea: A Meta-Analysis

Department of Otolaryngology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China

Correspondence should be addressed to Yong-Xiang Wei; moc.361@tnenehzna

Received 30 March 2017; Accepted 3 July 2017; Published 31 July 2017

Academic Editor: Betti Giusti

Copyright © 2017 Kun Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. “Sleep-related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research. The Report of an American Academy of Sleep Medicine Task Force,” Sleep, vol. 22, no. 5, pp. 667–689, 1999. View at Publisher · View at Google Scholar
  2. P. E. Peppard, T. Young, M. Palta, and J. Skatrud, “Prospective study of the association between sleep-disordered breathing and hypertension,” The New England Journal of Medicine, vol. 342, no. 19, pp. 1378–1384, 2000. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Qasim, S. A. Bukhari, M. J. Ghani et al., “Relationship of oxidative stress with elevated level of DNA damage and homocysteine in cardiovascular disease patients,” Pakistan Journal of Pharmaceutical Sciences, vol. 29, 6, pp. 2297–2302, Nov 2016. View at Google Scholar
  4. J. Selhub, “Homocysteine metabolism,” Annual Review of Nutrition, vol. 19, pp. 217–246, 1999. View at Publisher · View at Google Scholar · View at Scopus
  5. S. Seshadri, A. Beiser, J. Selhub et al., “Plasma homocysteine as a risk factor for dementia and Alzheimer's disease,” The New England Journal of Medicine, vol. 346, no. 7, pp. 476–483, 2002. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Suliman, P. Stenvinkel, A. R. Qureshi et al., “The reverse epidemiology of plasma total homocysteine as a mortality risk factor is related to the impact of wasting and inflammation,” Nephrology Dialysis Transplantation, vol. 22, no. 1, pp. 209–217, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. A. G. Bostom, H. Silbershatz, I. H. Rosenberg et al., “Nonfasting plasma total homocysteine levels and all-cause and cardiovascular disease mortality in elderly Framingham men and women,” Archives of Internal Medicine, vol. 159, no. 10, pp. 1077–1080, 1999. View at Publisher · View at Google Scholar · View at Scopus
  8. J. C. Chambers, A. McGregor, J. Jean-Marie, O. A. Obeid, and J. S. Kooner, “Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia: An effect reversible with vitamin C therapy,” Circulation, vol. 99, no. 9, pp. 1156–1160, 1999. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Kumor, R. Rubinsztajn, K. Byskiniewicz, P. Bielicki, and R. Chazan, “Serum concentration of homocysteine and the risk of atherosclerosis in patients with obstructive sleep apnea syndrome,” Pneumonologia I Alergologia Polska, vol. 74, no. 1, pp. 117–121, 2006. View at Google Scholar
  10. M. Can, Ş. Açikgöz, G. Mungan et al., “Serum cardiovascular risk factors in obstructive sleep apnea,” Chest, vol. 129, no. 2, pp. 233–237, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. M. H. D. K. Z. Lj, “The detection analysis of Homocysteine and lipid levels in OSAHS patients with cardiovascular disease,” Chinese Journal of Microcirculation, vol. 17, no. 4, p. 3, 2007. View at Google Scholar
  12. S. Ryan, G. M. Nolan, E. Hannigan, S. Cunningham, C. Taylor, and W. T. McNicholas, “Cardiovascular risk markers in obstructive sleep apnoea syndrome and correlation with obesity,” Thorax, vol. 62, no. 6, pp. 509–514, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. Y. Ozkan, H. Firat, B. Şimşek, M. Torun, and S. Yardim-Akaydin, “Circulating nitric oxide (NO), asymmetric dimethylarginine (ADMA), homocysteine, and oxidative status in obstructive sleep apnea-hypopnea syndrome (OSAHS),” Sleep and Breathing, vol. 12, no. 2, pp. 149–154, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. L. Wang, J. Li, Y. Xie, and X.-G. Zhang, “Association between serum homocysteine and oxidative stress in elderly patients with obstructive sleep apnea/hypopnea syndrome,” Biomedical and Environmental Sciences, vol. 23, no. 1, pp. 42–47, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. O. K. Basoglu, F. Sarac, S. Sarac, H. Uluer, and C. Yilmaz, “Metabolic syndrome, insulin resistance, fibrinogen, homocysteine, leptin, and C-reactive protein in obese patients with obstructive sleep apnea syndrome,” Annals of Thoracic Medicine, vol. 6, no. 3, pp. 120–125, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. L. V. Sales, V. M. S. Bruin, V. D'Almeida et al., “Cognition and biomarkers of oxidative stress in obstructive sleep apnea,” Clinics, vol. 68, no. 4, pp. 449–455, 2013. View at Publisher · View at Google Scholar · View at Scopus
  17. J. Li, L. Wang, M. Jiang, Y. Mao, and X. Pan, “Relationship between serum homocysteine level and oxidative stress in patients with obstructive sleep apnea-hypopnea syndrome,” Zhonghua Yi Xue Za Zhi, vol. 94, no. 32, pp. 2510–2513, 2014. View at Google Scholar · View at Scopus
  18. D. K. Andaku, V. D'Almeida, G. Carneiro, S. Hix, S. Tufik, and S. M. Togeiro, “Sleepiness, inflammation and oxidative stress markers in middle-aged males with obstructive sleep apnea without metabolic syndrome: A cross-sectional study,” Respiratory Research, vol. 16, no. 1, article no. 3, 2015. View at Publisher · View at Google Scholar · View at Scopus
  19. C. B. Begg and M. Mazumdar, “Operating characteristics of a rank correlation test for publication bias,” Biometrics, vol. 50, no. 4, pp. 1088–1101, 1994. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Egger, G. Davey Smith, M. Schneider, and C. Minder, “Bias in meta-analysis detected by a simple, graphical test,” British Medical Journal, vol. 315, no. 7109, pp. 629–634, 1997. View at Publisher · View at Google Scholar · View at Scopus
  21. F. Puig, F. Rico, I. Almendros, J. M. Montserrat, D. Navajas, and R. Farre, “Vibration enhances interleukin-8 release in a cell model of snoring-induced airway inflammation,” Sleep, vol. 28, no. 10, pp. 1312–1316, 2005. View at Publisher · View at Google Scholar · View at Scopus
  22. I. F. McDowell and D. Lang, “Homocysteine and endothelial dysfunction: a link with cardiovascular disease,” Journal of Nutrition, vol. 130, 2S, pp. 369S–372S, 2000. View at Google Scholar
  23. D. W. Jacobsen, “Hyperhomocysteinemia and oxidative stress time for a reality check?” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 20, no. 5, pp. 1182–1184, 2000. View at Publisher · View at Google Scholar · View at Scopus
  24. K. Katsoulis, T. Kontakiotis, D. Spanogiannis et al., “Total antioxidant status in patients with obstructive sleep apnea without comorbidities: the role of the severity of the disease,” Sleep & Breathing, vol. 15, no. 4, pp. 861–866, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. S. J. Jia, Y. Q. Lai, M. Zhao, T. Gong, and B. K. Zhang, “Homocysteine-induced hypermethylation of DDAH2 promoter contributes to apoptosis of endothelial cells,” Pharmazie, vol. 68, no. 4, pp. 282–286, 2013. View at Publisher · View at Google Scholar · View at Scopus