Inhibitory Effect of Chemical Constituents Isolated from Artemisia iwayomogi on Polyol Pathway and Simultaneous Quantification of Major Bioactive Compounds

Table 2

IC₅₀ of compounds 1–20 isolated from A. iwayomogi on aldose reductase (AR) and advanced glycation endproducts (AGEs) formation.

Compound	(μM)
	AR	AGEs formation
1
2
3	>200
4
5
6
7
8
9
10
11
12
13
14
15
16
17	>200	ND^d
18	>200	ND^d
19	>200	ND^d
20	>200
TMG^b		—
AG^c	—

IC₅₀ calculated from the least-squares regression line of the logarithmic concentrations plotted against the residual activity.
TMG was used as a positive control.
AG was used as a positive control.
ND was not detected.
Significant difference from control; , .