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BioMed Research International
Volume 2017, Article ID 7378148, 13 pages
https://doi.org/10.1155/2017/7378148
Research Article

miR-195-5p Suppresses the Proliferation, Migration, and Invasion of Oral Squamous Cell Carcinoma by Targeting TRIM14

1Medical College, Nankai University, Tianjin 300070, China
2Department of Oral and Maxillofacial Surgery, Chinese PLA General Hospital, Beijing 100853, China
3Department of Oral and Maxillofacial Surgery, Tianjin Stomatology Hospital, Tianjin 300041, China

Correspondence should be addressed to Lei Zhang; moc.361@latnedko and Rongfa Bu; moc.nuyila@ubafgnor

Received 30 June 2017; Revised 10 September 2017; Accepted 18 September 2017; Published 24 October 2017

Academic Editor: Takashi Saku

Copyright © 2017 Tong Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

MicroRNAs (miRNAs) play an essential role in tumor biological processes through interacting with specific gene targets. The involvement of miR-195-5p in cell proliferation, invasion, and migration has been demonstrated in several cancer cell lines, while its function in oral squamous cell carcinoma (OSCC) remains unclear. Here we find that miR-195-5p expression is lower in OSCC than in nontumor tissues, while its overexpression in cell lines can lead to the promotion of apoptosis and the reduction of cell growth, migration, and invasion. Moreover, we identify the tripartite motif-containing protein (TRIM14) as a target of miR-195-5p. Therefore, we reason that the tumor suppressor role of miR-195-5p in OSCC is dependent on the interaction with TRIM14.