A Review of Modern Control Strategies for Clinical Evaluation of Propofol Anesthesia Administration Employing Hypnosis Level Regulation

Table 3

Targeted control infusion (5 μg⋅ml⁻¹) based on calculated blood concentration using Paedfusor PK model.

	Blood concentration targeting	Effect site concentration targeting
Loading dose	1.7 mg⋅kg^−1	5.7 mg⋅kg^−1
Maximum blood target reached	5 mcg⋅kg^−1	12 mcg⋅kg^−1
Total Propofol infused after 60 min	23.2 mg⋅kg^−1	23.3 mg⋅kg^−1
Time to achieve effect site target of 5 mcg⋅ml^−1	17.5 min	4.5 min