Research Article

Association between Parathyroid Hormone, 25 (OH) Vitamin D, and Chronic Kidney Disease: A Population-Based Study

Table 1

Demographic characteristics of all patients and stratified by CKD .

All
Non-CKD
CKD
p

Age, years58.4 ± 13.356.5 ± 12.666.1 ± 12.9<0.001
Male, number (%)1480 (36.3%)1134 (34.6%)346 (42.9%)<0.001
Diabetes, number (%)722 (17.7%)410 (12.5%)312 (38.7%)<0.001
Hypertension, number (%)2197 (53.8%)1607 (49.3%)590 (73.2%)<0.001
Metabolic syndrome, number (%)1277 (31.3%)863 (26.4%)414 (51.3%)<0.001
Obesity, number (%)383 (9.4%)264 (8.1%)119 (14.7%)<0.001
Physical activity, min/day12.9 (0, 660)12.9 (0, 660)17.1 (0, 600)0.137
Smoking, number (%)1032 (25.3%)806 (24.6%)226 (28.0%)0.048
Alcohol drinking, number (%)642 (15.7%)534 (16.3%)108 (13.4%)0.040
Body mass index, kg/m224.9 ± 3.824.6 ± 3.726.0 ± 3.8<0.001
Systolic BP, mmHg131.9 ± 19.4129.6 ± 18.5141.3 ± 20.1<0.001
Diastolic BP, mmHg78.5 ± 11.977.7 ± 11.581.9 ± 12.8<0.001
Laboratory
 eGFR, mL/min per 1.73 m2 (MDRD)94.1 ± 26.398.3 ± 22.677.1 ± 32.6<0.001
 BUN, mg/dL13.7 ± 5.512.7 ± 3.717.5 ± 8.9<0.001
 Serum creatinine, mg/dL0.8 ± 0.30.7 ± 0.21.0 ± 0.5<0.001
 Serum albumin, g/dL4.7 ± 0.34.7 ± 0.34.6 ± 0.3<0.001
 Cholesterol, mg/dL209.7 ± 39.2210.1 ± 37.4208.2 ± 45.80.209
 Triglycerides, mg/dL128.4 ± 114.4121.4 ± 103.3156.5 ± 148.1<0.001
 hs-CRP, mg/L1.0 (0.2, 211.4)0.9 (0.2, 104.1)1.6 (0.2, 211.4)<0.001
 Urine albumin-to-creatinine ratio, g/g6.5 (0.4, 11067.4)5.4 (0.6, 29.8)49.7 (0.4, 11067.4)<0.001
 25 (OH) vitamin D, ug/mL29.4 ± 9.429.0 ± 9.031.1 ± 10.5<0.001
 iPTH, pmol/L43.0 (3.0, 898.9)42.2 (3.0, 311.2)46.3 (8.3, 898.9)<0.001
 Serum calcium, mg/dL9.4 ± 0.39.4 ± 0.39.4 ± 0.40.055
 Corrected calcium, mg/dL8.8 ± 0.38.8 ± 0.38.9 ± 0.4<0.001
 Serum phosphate, mg/dL3.8 ± 0.53.8 ± 0.53.8 ± 0.60.003
25 (OH) vitamin D status<0.001
 Vitamin D sufficient, number (%)1383 (33.9%)1042 (31.8%)341 (42.3%)
 Vitamin D deficient, number (%)2124 (52.1%)1755 (53.6%)369 (45.7%)
 Vitamin D insufficient, number (%)573 (14.0%)476 (14.5%)97 (12.0%)

The values are expressed as means (SD) or median (min, max).
Corrected calcium = serum calcium + 0.8 (4 − serum albumin).