Research Article

Proteomic Analysis of Liver Proteins in a Rat Model of Chronic Restraint Stress-Induced Depression

Table 2

Differentially expressed proteins in the liver of depression rats due to CRS.
(a) Upregulated proteins

ProteinsAccession numberControlCRS

Cluster of hemoglobin subunit beta-1P0209111.5
Cluster of alcohol dehydrogenase 1P067571.11.5
Dimethylaniline monooxygenase [N-oxide-forming] 5Q8K4C011.5
60S ribosomal protein L14Q6350711.5
60S ribosomal protein L35aP0464611.5
Cluster of KH domain-containing, RNA-binding, signal transduction-associated protein 1Q91V3311.5
40S ribosomal protein S29P6227511.5
60S ribosomal protein L29P2588611.5
3-oxo-5-alpha-steroid 4-dehydrogenase 1P2400811.5
Sodium channel and clathrin linker 1Q8CJ9911.5
Sperm-associated antigen 1Q5U2X211.5
Multidrug resistance protein 1P4324511.5
TransgelinP3123211.5
Copper-transporting ATPase 1P7070511.5
Leucine zipper putative tumor suppressor 2Q3LUD411.5
Geranylgeranyl transferase type-2 subunit betaQ0860311.5
Tissue alpha-L-fucosidaseP1716411.5
DNA (cytosine-5)-methyltransferase 3AQ1LZ530.91.5
Interleukin enhancer-binding factor 2Q7TP9811.5
Histone H1.5D3ZBN011.5
GametogenetinQ66HC811.5
Alpha-mannosidase 2C1P211390.91.5
ATP-binding cassette sub-family D member 2Q9QY4411.5
Centrosomal protein of 63 kDaQ4KLY011.5
PHD finger protein 7Q6AXW411.5
Tyrosine-protein kinase SYKQ6472511.5
Pleckstrin homology domain-containing family
H member 3
Q3B7L111.5
Coronin-6Q920J311.5
Testis-specific protein 10-interacting proteinQ66MI611.5
60S ribosomal protein L7aP6242511.6
60S ribosomal protein L28P1770211.6
60S ribosomal protein L34P1125011.6
Aminoacyl tRNA synthase complex-interactin multifunctional protein 2Q32PX211.6
Dipeptidyl peptidase 2Q9EPB111.6
N-acetylgalactosamine-6-sulfataseQ32KJ611.6
Lys-63-specific deubiquitinase BRCC36B2RYM511.6
Cytochrome P450 2B15Q6458311.6
Cluster of beta-adrenergic receptor kinase 2P2681911.6
Beta-adrenergic receptor kinase 2P2681911.6
Sterol regulatory element-binding protein 1P5672011.6
Cystic fibrosis transmembrane conductance regulatorP341580.91.6
Uncharacterized protein C4orf51 homologQ4V7B211.6
60S ribosomal protein L6P2153311.7
60S ribosomal protein L35P1707811.7
Peroxisomal membrane protein 11AO7059711.7
Galactose-1-phosphate uridylyltransferaseP4342411.7
Protein MEMO1Q4QQR911.7
39S ribosomal protein L17, mitochondrialQ6PDW611.7
Exocyst complex component 4Q6282411.8
Homeodomain-interacting protein kinase 4Q4V79311.8
Neurexin-3-alphaQ0731011.8
Mast cell protease 1P0965011.8
Ras GTPase-activating protein 1P5090411.9
Cluster of histone H1.4P1586512
Rho guanine nucleotide exchange factor 11Q9ES6712.1
Protein kinase C eta typeQ6461712.1
DnaJ homolog subfamily C member 10Q498R312.3
Potassium voltage-gated channel subfamily H member 6O5485312.3
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2Q8CGU412.5
Acetoacetyl-CoA synthetaseQ9JMI112.6
NTF2-related export protein 2B2GV7712.8
Replication factor C subunit 2Q641W413
Diacylglycerol O-acyltransferase 2Q5FVP813.2
Focal adhesion kinase 1O3534613.3
Cytochrome P450 2A3P2081214.1
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8P6307714.5
Potassium voltage-gated channel subfamily H member 5Q9EPI90.94.9
Collagen alpha-1 (II) chainP0553915.6
Zinc finger protein 574Q504L706.5
Phosphatidylinositol-binding clathrin assembly proteinO5501219.3
Sister chromatid cohesion protein PDS5 homolog AA4L9P7124.1

(b) Down-regulated proteins

ProteinsAccession No.ControlCRS

Tyrosine-protein phosphatase non-receptor type 2P3523310.1
Zinc finger FYVE domain-containing protein 26D4A8G910.4
Homeobox protein OTX1Q6341010.4
FurinP2337710.5
Cytochrome P450 2C12, female-specificP1151010.5
CST complex subunit STN1Q6AYD20.90.5
Galectin-8Q6266510.5
Zinc finger and BTB domain-containing protein 24Q3B72510.5
Dual specificity testis-specific protein kinase 1Q6357210.5
Mothers against decapentaplegic homolog 3P8402510.5
Multiple coagulation factor deficiency protein 2 homologQ8K5B310.6
Metabotropic glutamate receptor 1P2338510.6
PRA1 family protein 3Q9ES4010.6
Cluster of ATP-binding cassette sub-family C member 8Q0942910.6
ATP-binding cassette sub-family C member 8Q0942910.6
Calcium-transporting ATPase type 2C member 1Q6456610.6
Vacuolar protein sorting-associated protein 33BQ6361610.6
Adaptin ear-binding coat-associated protein 1P6968210.6
Cyclin-dependent kinase 9Q641Z410.6
Zinc fingers and homeobox protein 1Q8R51510.6
Pyridoxal phosphate phosphataseQ8VD5210.6
N-alpha-acetyltransferase 11Q4V8K310.6
Protein jagged-1Q6372210.6
Protein kinase C delta typeP0921510.6
Lipase maturation factor 2A1L1J910.6
Activin receptor type-2BP3844510.6
Keratin, type I cytoskeletal 39Q6IFW310.6