Proanthocyanidins Attenuation of H₂O₂-Induced Oxidative Damage in Tendon-Derived Stem Cells via Upregulating Nrf-2 Signaling Pathway

Figure 3

PCs reduced H₂O₂-induced oxidative stress in TDSCs. (a) PCs had no cytotoxic effects on TDSCs (). (b) H₂O₂ reduced cell viability (%) in TDSCs; data are percentage of cell viability in comparison to the control group, and viability in the 400 μmol/ml was approximately 50%, reflecting IC50. (c) PCs protected TDSCs against H₂O₂-induced oxidative stress. Obvious differences were observed between the non-PCs and pre-PCs treatment groups, but no significant differences were found among groups pretreated with PCs at various concentrations. H₂O₂ (+): 400 μmol/ml. All results were expressed as the mean ± SD (); , as compared to control group.

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