BioMed Research International

Review Article

Responders to Platelet-Rich Plasma in Osteoarthritis: A Technical Analysis

Table 2

The outcomes assessed and reported by each author. K-L score = Kellgren-Lawrence classification score; ref = references; stage = stage of osteoarthritis; VAS = visual analogic scale; + = >2xMCII (VGRG); 0 = 2xMCII > 0 > 1xMCII; − = <MCII (BRG).
RefStageWOMACVASIKDCKOOSEfficacy
Vaquerizo et al. [25]K-L score: 2 to 4WOMAC total score: change from baseline −42% at 24 weeks, −34% at 48 weeks—— +
Patel et al. [26]Ahlbäck grade 1 or 2 (3) without deformationWOMAC total score: change at 6 months: −51% (1 inj PRP), −43% (2 inj PRP)   +
Filardo et al. [27]K-L score: 0 to 3   No improvement >15 in absolute value at 6 and 12 months and no statistically significant difference with HA−
Cerza et al. [28]K-L score: 1, 2, 3WOMAC score before treatment: 79,6;
24 weeks: 36,5;
difference: −43,1		   +
Sánchez et al. [29]Ahlbäck grade < 4WOMAC total score improvement: 35,1%   0
Say et al. [30]K-L score: 1, 2, 3   KOOS 46 at baseline; 84,4 at 6 months, +38,4/100, absolute value+
Spaková et al. [31]K-L score: 1, 2, 3WOMAC OA index: 38,76 at baseline; 14,35 at 3 months; improvement: 24,41 — 0
Filardo et al. [32]K-L score: 0; 1 to 3; 4— IKDC from 45.0 at baseline to 61,3 at 6 months in PRGF group (increase 16,3) and from 42,1 at baseline to 62,5 at 6 months in PRP group (increase 20,4) 0
Kon et al. [33]K-L score: 0; 1 to 3; 4—53,6 at baseline to 72,3 at 6 months (18,7)IKDC: 41,2 at baseline; 64,00 at 6 months (increase 22,8) 0
Acosta-Olivo et al. [20]K-L score: 1—   KOOS: from 30,1 to 48.2 (60%)Relative improvement: very good (not for absolute value)
Kon et al. [34]K-L score: 0, 1–3, 4—Basal 50.9 = chondropathy; 51.8 = early OA; 50.3 = advanced OA
2 months 75.6–71.6–14.9 60.0–16.4
6 months 78.0–67.5–57.1
12 months 78.9–69.2–56.9		Basal 43.1–40.0–34.9
2 months 70.1–59.5–48.1
6 months 72.4–58.9–44.2
12 months 68.7–56.8–46.4		 0
Filardo et al. [35]K-L score: 0, 1–3, 4— Follow-up of KON at 24 months: 50 to 70 at 12 months to 60 at 24 monthsThe IKDC objective score increased from 47% of normal and nearly normal knees before the treatment to 78% at the end, 73 and 67% at the 6- and 12-month follow-ups. The evaluation after 24 months showed a drop () in the score to 59%. IKDC subj: 40 to 60 at 12 months, 51 at 24 months 0
Sampson et al. [36]History of gonarthrosis, primary or secondary for more than 3 months—Rest: 2.5 at baseline; 0.8 at 52 weeks
Moving: 4.6 at baseline; 2.5 at 52 weeks
Bent knee: 2.8 at baseline; 1.3 at 52 weeks		—Pain: 35.3–48.1 (12.8)
Symptom relief: 36.1–43.9 (7.8)
Activity of daily living: 44.8–54.3 (9.5)
Sports: 9.6–20 (10.4)
Quality of life: 1.0–13.4 (12.4)		−
Wang-Saegusa et al. [37]Outer bridge grades I–IV (MRI) The patients follow-up
improvement was 65.5, 48.2, and 67.4% for pain, stiffness,
and functional capacity, respectively		The VAS score for pain was 4.86 before treatment and 3.32 follow-up——+
Gobbi et al. [38]K-L score: 1 to 3—Before 6 months–12 months: 4,1–2,2–1,2IKDC (PRE-6 months–12 months)
48.2–65.2–75.4		KOOS
Pain 73.6 ± 4.3
81.9 ± 4.3
88.7 ± 2.9
32.333
Symptoms 72.0 ± 4.1
78.2 ± 4.2
86.4 ± 3.2
27.674
Activities of daily living 77.8 ± 5.7
86.3 ± 4.7
94.8 ± 2.5
19.163
Sport 42.3 ± 7.3
50.6 ± 7.6
63.8 ± 6.7
22.176
Quality of life 41.3 ± 5.3
52.5 ± 5.2
68.0 ± 5.6
43.305		0
Napolitano et al. [39]K-L score: 1 to 3Arthritis: (A) pain, before treatment , after treatment , and, for 7 patients, at the 6-month follow-up ;
(B) joint stiffness, before treatment , after treatment , and at the 6-month follow-up ;
(C) function, before treatment , after treatment , and at the 6-month follow-up  
Cartilage disease: (A) pain, before treatment , after treatment and, for 6 patients, at the 6-month follow-up ;
(B) joint stiffness, before treatment , after treatment , and at the 6-month follow-up ;
(C) function, before treatment , after treatment		   −
Halpern et al. [40]K-L score: 0, 2WOMAC total 45,1% change from baseline at 6 months; 56,2% at 12 monthsVAS pain at 6 months 56,2% change from baseline; 58,9% at 12 months  +
Jang et al. [41]K-L score: 1 to 3 VAS score improved from 7.4 before the procedure to 5.0, 4.5, and 4.2 for 1, 3, and 6 months after procedureIKDC score changed from 54.1 before the procedure to 53.9 at 1 month after procedure, 61.6 at 6 months after procedure, and 50.3 at 1 year after procedure—0
Filardo et al. [21]K-L score: 0 to 3  IKDC subjective score: 52.4 at baseline; 65.0 at 6 months; 66.2 at 12 monthsKOOS score: (baseline – 6 months (diff))
Symptom 65.5–74.7 (9.2)
Pain: 66.1–74.7 (8.6)
ADL: 70.6–79.1 (8.5)
Sport: 37.9–49.6 (11.7)
QOL: 36.0–49.2 (13.2)		−