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BioMed Research International
Volume 2017, Article ID 7585989, 8 pages
Research Article

Human Gut Microbiota Associated with Obesity in Chinese Children and Adolescents

1Medical Genetic Centre, Guangdong Women and Children Hospital, Guangzhou, Guangdong 510010, China
2Maternal and Children Metabolic-Genetic Key Laboratory, Guangdong Women and Children Hospital, Guangzhou, Guangdong 510010, China
3CapitalBio Genomics Co., Ltd., Dongguan 532808, China
4Department of Pediatrics, Guangdong Women and Children Hospital, Guangzhou, Guangdong 510010, China

Correspondence should be addressed to Hai-Liang Liu; moc.scimoneglatipac@uillh and Ai-Hua Yin; moc.621.piv@awianiy

Received 5 June 2017; Revised 4 September 2017; Accepted 27 September 2017; Published 29 October 2017

Academic Editor: Koichiro Wada

Copyright © 2017 Ya-Ping Hou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. To investigate the gut microbiota differences of obese children compared with the control healthy cohort to result in further understanding of the mechanism of obesity development. Methods. We evaluated the 16S rRNA gene, the enterotypes, and quantity of the gut microbiota among obese children and the control cohort and learned the differences of the gut microbiota during the process of weight reduction in obese children. Results. In the present study, we learned that the gut microbiota composition was significantly different between obese children and the healthy cohort. Next we found that functional changes, including the phosphotransferase system, ATP-binding cassette transporters, flagellar assembly, and bacterial chemotaxis were overrepresented, while glycan biosynthesis and metabolism were underrepresented in case samples. Moreover, we learned that the amount of Bifidobacterium and Lactobacillus increased among the obese children during the process of weight reduction. Conclusion. Our results might enrich the research between gut microbiota and obesity and further provide a clinical basis for therapy for obesity. We recommend that Bifidobacterium and Lactobacillus might be used as indicators of healthy conditions among obese children, as well as a kind of prebiotic and probiotic supplement in the diet to be an auxiliary treatment for obesity.