Research Article

The Effect of Phototherapy on Cancer Predisposition Genes of Diabetic and Normal Human Skin Fibroblasts

Table 4

Cancer-related predisposition genes that were overexpressed after blue, green, or red light irradiation in normal healthy fibroblast cells (nondiabetic patients) ().

Light conditionOverexpressed genes after irradiation Possible cancers affected

BlueBUB1BBrain and lung cancer
ERCC5Ovarian cancer
FANCD2Breast cancer and Fanconi anemia
MSR1Prostate cancer and Barrett’s esophagus/esophageal adenocarcinoma

GreenANTXR2Hyaline fibromatosis syndrome and hyalinosis, inherited systemically (its related pathways are infectious disease and uptake and actions of bacterial toxins)
BUB1BBrain and lung cancers
DIS3L2Perlman syndrome and Wilms’ tumor susceptibility-5
EPCAMEndometrial cancer, biliary tract cancer, and skin cancer
ESCO2Roberts syndrome and SC phocomelia syndrome
EPHB2Prostate cancer/brain cancer susceptibility, somatic and prostate cancer
EXT1Chondrosarcoma and exostoses, multiple, type 1
FANCD2Breast cancer and Fanconi anemia
KITEndometrial cancer as a gastrointestinal stromal tumor
MSR1Prostate cancer and Barrett’s esophagus/esophageal adenocarcinoma
NF1Neurofibromatosis-Noonan syndrome and neurofibromatosis, type 1
RETMultiple endocrine neoplasia iia and medullary thyroid carcinoma, familial
TSC1Tuberous sclerosis-1 and lymphangioleiomyomatosis

RedBUB1BBrain and lung cancer
DIS3L2Perlman syndrome and Wilms’ tumor susceptibility-5
FANCBFanconi anemia, complementation group B, and Fanconi anemia, complementation group A
FANCD2Breast cancer and Fanconi anemia
KITEndometrial cancer as a gastrointestinal stromal tumor
MSR1Prostate cancer and Barrett’s esophagus/esophageal adenocarcinoma
POLEFILS syndrome and colorectal cancer 12
POLHXeroderma pigmentosum, variant type and POHL-related xeroderma pigmentosum
RETMultiple endocrine neoplasia iia and medullary thyroid carcinoma, familial
SUFUMedulloblastoma and basal cell nevus syndrome
TMC8Epidermodysplasia verruciformis and superficial mycosis