Research Article

The Effect of Phototherapy on Cancer Predisposition Genes of Diabetic and Normal Human Skin Fibroblasts

Table 5

Cancer-related predisposition genes that were overexpressed after blue, green, or red light irradiation in diabetic fibroblast cells ().

Light conditionOverexpressed genes after irradiation Possible cancers affected

BlueBUB1BBrain and lung cancers
BMPR1APolyposis syndrome, hereditary mixed, 2 and polyposis, juvenile intestinal
EHBP1Prostate cancer, hereditary, 12 and prostate cancer
EPHB2Prostate cancer/brain cancer susceptibility, somatic and prostate cancer
FANCD2Breast cancer and Fanconi anemia
KDRHemangioma, capillary infantile and hemangioma
PDE11APigmented nodular adrenocortical disease, primary, 2 and primary pigmented nodular adrenocortical disease
RETMultiple endocrine neoplasia iia and medullary thyroid carcinoma, familial
RUNX1Platelet disorder, familial, with associated myeloid malignancy and isolated delta-storage pool disease (among its related pathways are endometrial cancer and chronic myeloid leukemia)

GreenEPHB2Prostate cancer/brain cancer susceptibility, somatic and prostate cancer
NF1Neurofibromatosis-Noonan syndrome and neurofibromatosis, type 1
SDHCParagangliomas 3 and paraganglioma and gastric stromal sarcoma (among its related pathways are Alzheimer’s disease and carbon metabolism)

RedAXIN2Oligodontia-colorectal cancer syndrome and colorectal cancer
EHBP1Prostate cancer, hereditary, 12 and prostate cancer
EPHB2Prostate cancer/brain cancer susceptibility, somatic and prostate cancer
GLMNGlomuvenous malformations and glomangioma
GPC3Simpson-Golabi-Behmel syndrome, type 1 and Wilms tumor susceptibility-5
KDRHemangioma, capillary infantile and hemangioma
KITEndometrial cancer in gastrointestinal stromal tumor
MSMBProstate cancer, hereditary, 13 and prostate cancer
MSR1Prostate cancer and Barrett esophagus/esophageal adenocarcinoma
PDGFRAGastrointestinal stromal tumor and hypereosinophilic syndrome, idiopathic, resistant to imatinib
RUNX1Platelet disorder, familial, with associated myeloid malignancy and isolated delta-storage pool disease (among its related pathways are endometrial cancer and chronic myeloid leukemia)