Circulating MicroRNAs as Potential Biomarkers of Atrial Fibrillation

Table 1

Principal circulating miRNAs involved with atrial fibrillation.

Authors	Casuistic	Upregulated	Downregulated
Liu et al., 2012			miR-19a
	30 PAF and 30 PersAF		miR-146a
	30 no AF		miR-150
			miR-375
Dawson et al., 2013	16 AF with CHF and 17 AF without CHF		miR-21
	32 no AF with CHF and 30 controls		miR-29b
Nishi et al., 2013	16 AF		miR-21
	4 no AF
McManus et al., 2014	2185 no AF		miR-328
	153 AF (prevalent )
Goren et al., 2014	15 AF with HF		miR-150
	26 HF without AF and 35 controls
Soeki et al., 2016	20 PAF and 10 PersAF (undergoing PV isolation)	miR-1
	10 Wolff-Parkinson-White syndrome (no AF)	miR-328
Wei et al., 2015	35 AF and 36 AF with HF		miR-126
	32 HF without AF and 32 controls
McManus et al., 2015	112 AF		miR-21
	99 no AF		miR-150
Lu et al., 2015		miR-9	miR-1; miR-145; miR-162; miR-222; miR-328; miR-432; miR-493b
		miR-19
		miR-146
	112 AF	miR-152
	112 no AF	miR-374a
		miR-454
		miR-634
		miR-664
Hoffmann et al., 2016	17 AF T/T genotype		miR-92b-5p (AF carrying the SHOX2
	6 AF T/C genotype		3′UTR c.28C allele)
Harling et al., 2017	13 AF	miR-483-5p
	21 no AF
Liu et al., 2016	88 PAF, 8 PersAF, and 4 long-standing PersAF		miR-409-3p
			miR-432
	100 no AF		miR-328

PAF, paroxysmal AF; PersAF, persistent AF; CHF, congestive heart failure; PV, pulmonary vein.