Skeletal Muscle and Lymphocyte Mitochondrial Dysfunctions in Septic Shock Trigger ICU-Acquired Weakness and Sepsis-Induced Immunoparalysis

Figure 3

Time course of mitochondrial impairment and mitochondrial biogenesis following sepsis in peripheral blood mononuclear cells (PBMCs). TNFα: tumor necrosis factor α; Il-6: interleukin-6; ROS: reactive oxygen species; SOD: superoxide dismutase, GPx: glutathione peroxidase; NRF-1/2: nuclear respiratory factor 1/2; PGC-1α: peroxisome proliferator-activated receptor-γ coactivator 1α; Tfam: mitochondrial transcription factor A. Adapted from Lejay et al. with permission [27].