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BioMed Research International
Volume 2017, Article ID 7901763, 12 pages
Research Article

Candidemia in the Neonatal Intensive Care Unit: A Retrospective, Observational Survey and Analysis of Literature Data

1Department of Biomedical Science and Human Oncology, Hygiene Section, University of Bari “Aldo Moro”, Bari, Italy
2Department of Biomedical Science and Human Oncology, General Pathology Section, University of Bari “Aldo Moro”, Bari, Italy
3Neonatology and NICU Section, Azienda Ospedaliero-Universitaria Policlinico of Bari, Bari, Italy
4Department of Biomedical Science and Human Oncology, Neonatology and NICU Section, University of Bari “Aldo Moro”, Bari, Italy

Correspondence should be addressed to Giuseppina Caggiano; ti.abinu@onaiggac.anippesuig

Received 16 March 2017; Accepted 18 June 2017; Published 13 August 2017

Academic Editor: Stanley Brul

Copyright © 2017 Giuseppina Caggiano et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We evaluated the epidemiology of Candida bloodstream infections in the neonatal intensive care unit (NICU) of an Italian university hospital during a 9-year period as a means of quantifying the burden of infection and identifying emerging trends. Clinical data were searched for in the microbiological laboratory database. For comparative purposes, we performed a review of NICU candidemia. Forty-one candidemia cases were reviewed (overall incidence, 3.0 per 100 admissions). Candida parapsilosis sensu stricto (58.5%) and C. albicans (34.1%) were the most common species recovered. A variable drift through years was observed; in 2015, 75% of the cases were caused by non-albicans species. The duration of NICU hospitalization of patients with non-albicans was significantly longer than in those with C. albicans (median days, 10 versus 12). Patients with non-albicans species were more likely to have parenteral nutrition than those with C. albicans (96.3% versus 71.4%). Candida albicans was the dominant species in Europe and America (median, 55% and 60%; resp.); non-albicans species predominate in Asia (75%). Significant geographic variation is evident among cases of candidemia in different parts of the world, recognizing the importance of epidemiological data to facilitate the treatment.