Enhancement of Bone-Marrow-Derived Mesenchymal Stem Cell Angiogenic Capacity by NPWT for a Combinatorial Therapy to Promote Wound Healing with Large Defect

Figure 4

Evaluation of wound tissues. (a) Representative gross photos of the wounds treated with sham operation, BMSCs, NPWT, and BMSCs + NPWT. (b) Wound closure curves demonstrated significantly accelerated wound healing in BMSC + NPWT group. (c) H&E staining, Masson’s trichrome staining, and picrosirius red staining of wounds at day 9. Data is given as the mean ± SD, , , and untreated versus BMSC + NPWT at different time points, respectively; NPWT versus BMSC + NPWT; local BMSC injection versus BMSC + NPWT.

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