Recombinant Immunotoxin Therapy of Glioblastoma: Smart Design, Key Findings, and Specific Challenges

Figure 1

Design of the antibody fragments for construction of recombinant immunotoxins. The left panel shows the “Y”-shape structure of IgG monoclonal antibodies, and the middle and right panels demonstrate the linear and cartoon structures of various antibody fragments. , the heavy variable region; , the light variable region.