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BioMed Research International
Volume 2017, Article ID 7963747, 6 pages
Research Article

Thiocarbamates from Moringa oleifera Seeds Bioactive against Virulent and Multidrug-Resistant Vibrio Species

1Federal University of Ceará, Fortaleza, CE, Brazil
2Sea Sciences Institute, Federal University of Ceará, Fortaleza, CE, Brazil
3Oswaldo Cruz Institute, Rio de Janeiro, RJ, Brazil
4Department of Organic and Inorganic Chemistry, Federal University of Ceará, Fortaleza, CE, Brazil

Correspondence should be addressed to Renata Albuquerque Costa; moc.liamg@qubla.ataner

Received 31 March 2017; Accepted 31 May 2017; Published 9 July 2017

Academic Editor: Veronica Lazar

Copyright © 2017 Renata Albuquerque Costa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Prospect of antibacterial agents may provide an alternative therapy for diseases caused by multidrug-resistant bacteria. This study aimed to evaluate the in vitro bioactivity of Moringa oleifera seed extracts against 100 vibrios isolated from the marine shrimp Litopenaeus vannamei. Ethanol extracts at low (MOS-E) and hot (MOS-ES) temperature are shown to be bioactive against 92% and 90% of the strains, respectively. The most efficient Minimum Inhibitory Concentration (MIC) levels of MOS-E and MOS-ES against a high percentage of strains were 32 µg mL−1. Bioguided screening of bioactive compounds showed that the ethyl acetate fraction from both extracts was the only one that showed antibacterial activity. Vibriocidal substances, niazirine and niazimicine, were isolated from the aforementioned fraction through chromatographic fractionation.