Δ⁹-Tetrahydrocannabinol Prevents Cardiovascular Dysfunction in STZ-Diabetic Wistar-Kyoto Rats

Table 1

Physiological and biochemical parameters following THC administration to control and diabetic rats.

Parameter	WKY	WKY + THC	STZ	STZ + THC
Systolic blood pressure (mmHg)	149 ± 11	144 ± 8	133 ± 4	143 ± 5
Heart rate (beats per minute)	439 ± 4	409 ± 1
Change in body mass (% change over treatment period)	51.6 ± 2.9	39.8 ± 3.	21.4 ± 3.	35.9 ± 4.
Left ventricular mass (mg gram body mass^−1)	2.32 ± 0.03	2.43 ± 0.19	3.13 ± 0.1	2.65 ± 0.0
Right ventricular mass (mg gram body mass^−1)	0.51 ± 0.02	0.56 ± 0.09	0.87 ± 0.0	0.75 ± 0.0
Kidney mass (mg gram body mass^−1)	6.07 ± 0.12	6.17 ± 0.42	10.15 ± 0.4	7.68 ± 0.3
Blood glucose (mmol L^−1)	9.8 ± 0.6	11.9 ± 0.	30.5 ± 1.	24.2 ± 2.
Nitric oxide end products (µmol)	6.1 ± 0.5	4.6 ± 0.3	2.9 ± 0.	4.0 ± 0.
Serum Malondialdehyde (µmol)	62.2 ± 2.7	13.4 ± 0.	94.3 ± 2.	53.7 ± 4.
Serum Interleukin-1β (ng mL^−1)	4.8 ± 0.1	4.9 ± 0.1	4.7 ± 0.04	4.4 ± 0.0
Serum Interleukin-6 (ng mL^−1)	3.1 ± 0.1	3.1 ± 0.1	2.7 ± 0.	3.0 ± 0.0

All data are presented as mean ± standard error of the mean; versus WKY and versus STZ.