Basal and Activated Calcium Sensitization Mediated by RhoA/Rho Kinase Pathway in Rats with Genetic and Salt Hypertension

Figure 4

Relative BAY K8644-induced MAP changes (in percentage of maximal MAP responses) seen in the absence and in the presence of fasudil in rats with inhibited RAS and SNS. (a) WKY and SHR rats, (b) HanSD and TGR animals, (c) salt-sensitive (SS/Jr) Dahl rats fed either low-salt (LS) or high-salt (HS) diet, and (d) salt-resistant (SR/Jr) animals (Experiment ). Data are mean ± SEM; for number of rats see Table 3. The statistical analysis revealed significant differences in relative fasudil-sensitive component of maximal MAP responses (SHR − versus WKY −%, ; TGR − versus HanSD −%, ), whereas the difference in Dahl salt-sensitive rats did not achieve statistical significance (SS/Jr-HS − versus SS/Jr-LS −%).

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