Basal and Activated Calcium Sensitization Mediated by RhoA/Rho Kinase Pathway in Rats with Genetic and Salt Hypertension

Table 1

Initial values of mean arterial pressure (MAP, mm Hg) and MAP changes induced by fasudil and additional nifedipine as well as MAP levels reached after inhibitors administration in spontaneously hypertensive rats (SHR) and Wistar-Kyoto controls (WKY), heterozygous Ren-2 transgenic rats (TGR), and Hannover Sprague Dawley controls (HanSD) as well as in salt-sensitive (SS/Jr) and salt-resistant (SR/Jr) Dahl rats fed either a low-salt (LS) or high-salt (HS) diet (Experiment ).

Strain	Number of rats	Initial MAP	Delta MAP fasudil	MAP after fasudil	Delta MAP; additive nifedipine	MAP after fasudil + nifedipine
SHR	10
WKY	8
TGR	12
HanSD	11
SS/Jr-HS	6
SS/Jr-LS	6
SR/Jr-HS	8
SR/Jr-LS	8

Data are means ± SEM. Significantly different ()from the respective normotensive controls and ^#from the corresponding rat strain fed a low-salt diet.