Research Article

Potential Anticancer Mechanisms of a Novel EGFR/DNA-Targeting Combi-Molecule (JDF12) against DU145 Prostate Cancer Cells: An iTRAQ-Based Proteomic Analysis

Table 1

Differentially expressed proteins detected by iTRAQ after being treated with JDF12 in DU145 cells.

NumberAccession
number
Gene
name
Protein nameFold change

Upregulated proteins
(1)Q5T2R2PDSS1Decaprenyl-diphosphate synthase subunit 134.52
(2)Q96HN1PLEKHG4BPLEKHG4B protein (Fragment)10.23
(3)Q14914PTGR1Prostaglandin reductase 13.78
(4)P09914IFIT1Interferon-induced protein with tetratricopeptide repeats 13.46
(5)A0A0C4DGB6ALBSerum albumin2.47
(6)C9JIZ6PSAPProsaposin2.42
(7)Q53EL6PDCD4Programmed cell death protein 42.41
(8)F8W8T1MX1Interferon-induced GTP-binding protein Mx12.30
(9)P09382LGALS1Galectin-12.27
(10)H0YIV4NAP1L1Nucleosome assembly protein 1-like 12.17
(11)P18669PGAM1Phosphoglycerate mutase 12.14
(12)P12883MYH7Myosin-72.11
(13)P16615ATP2A2Sarcoplasmic/endoplasmic reticulum calcium ATPase 22.05
(14)P49006MARCKSL1MARCKS-related protein2.02
(15)Q6PJG6BRAT1BRCA1-associated ATM activator 11.97
(16)Q9Y5A7NUB1NEDD8 ultimate buster 11.96
(17)Q03169TNFAIP2Tumor necrosis factor alpha-induced protein 21.92
(18)Q99536VAT1Synaptic vesicle membrane protein VAT-1 homolog1.92
(19)P38919EIF4A3Eukaryotic initiation factor 4A-III1.91
(20)Q96AQ6PBXIP1Pre-B-cell leukemia transcription factor-interacting protein 11.89
(21)Q9UIJ7AK3GTP: AMP phosphotransferase AK3, mitochondrial1.84
(22)P04080CSTBCystatin-B1.83
(23)P12277CKBCreatine kinase B-type1.83
(24)P62937PPIAPeptidyl-prolyl cis-trans isomerase A1.82
(25)P52630STAT2Signal transducer and activator of transcription 21.81
(26)P14625HSP90B1Endoplasmin1.80
(27)Q6PJG6BART1BRCA1-associated ATM activator 11.79
(28)Q9BTT0ANP32EAcidic leucine-rich nuclear phosphoprotein 32 family member E1.79
(29)Q01581HMGCS1Hydroxymethylglutaryl-CoA synthase, cytoplasmic1.79
(30)Q5T9B7AK1Adenylate kinase isoenzyme 11.78
(31)J3KQL8APOL2Apolipoprotein L21.76
(32)P62750RPL23A60S ribosomal protein L23a1.75
(33)Q14980NUMA1Nuclear mitotic apparatus protein 11.73
(34)P28066PSMA5Proteasome subunit alpha type-51.72
(35)P23528CFL1Cofilin-11.71
(36)Q8IY63AMOTL1Angiomotin-like protein 11.71
(37)Q8TBX8PIP4K2CPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma1.70
(38)P28799GRNGranulins1.68
(39)P04792HSPB1Heat shock protein beta-11.67
(40)P11021HSPA578 kDa glucose-regulated protein1.67
(41)A0A0A0MSZ4FDXRNADPH: adrenodoxin oxidoreductase, mitochondrial1.65
(42)O94992HEXIM1Protein HEXIM11.65
(43)P31949S100A11Protein S100-A111.64
(44)Q04828AKR1C1Aldo-keto reductase family 1 member C11.63
(45)Q13263TRIM28Transcription intermediary factor 1-beta1.63
(46)Q8IVF2AHNAK2Protein AHNAK21.63
(47)Q9NVP2ASF1BHistone chaperone ASF1B1.63
(48)O75874IDH1Isocitrate dehydrogenase [NADP] cytoplasmic1.62
(49)O96008TOMM40Mitochondrial import receptor subunit TOM40 homolog1.61
(50)P27449ATP6V0CV-type proton ATPase 16 kDa proteolipid subunit1.61
(51)P06733ENO1Alpha-enolase1.60
(52)Q00688FKBP3Peptidyl-prolyl cis-trans isomerase FKBP31.60
(53)A0A0U1RQC9TP53Cellular tumor antigen p531.59
(54)Q9Y6K5OAS32′-5′-Oligoadenylate synthase 31.59
(55)P46977STT3ADolichyl-diphosphooligosaccharide—protein glycosyltransferase subunit STT3A1.58
(56)Q9UNS1TIMELESSProtein timeless homolog1.58
(57)E9PFR3PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform1.57
(58)Q14764MVPMajor vault protein1.57
(59)O75083WDR1WD repeat-containing protein 11.56
(60)P04075ALDOAFructose-bisphosphate aldolase A1.56
(61)P09601HMOX1Heme oxygenase 11.56
(62)Q16678CYP1B1Cytochrome P450 1B11.56
(63)P62158CALM1Calmodulin1.55
(64)Q06830PRDX1Peroxiredoxin-11.55
(65)P13667PDIA4Protein disulfide-isomerase A41.54
(66)P22223CDH3Cadherin-31.54
(67)P15121AKR1B1Aldose reductase1.53
(68)P30050RPL1260S ribosomal protein L121.53
(69)Q9BXP5SRRTSerrate RNA effector molecule homolog1.52
(70)H0Y4G9MYD88Myeloid differentiation primary response protein MyD881.50
Downregulated proteins
(71)P13645KRT10Keratin, type I cytoskeletal 100.27
(72)O95155UBE4BUbiquitin conjugation factor E4 B0.38
(73)Q9BYX7POTEKPPutative beta-actin-like protein 30.39
(74)P26599PTBP1Polypyrimidine tract-binding protein 10.44
(75)P52789HK2Hexokinase-20.44
(76)Q53EP0FNDC3BFibronectin type III domain-containing protein 3B0.44
(77)P35908KRT2Keratin, type II cytoskeletal 2 epidermal0.45
(78)P04264KRT1Keratin, type II cytoskeletal 10.45
(79)O43854EDIL3EGF-like repeat and discoidin I-like domain-containing protein 30.46
(80)F5H039GPHNGephyrin0.48
(81)F8W727RPL3260S ribosomal protein L320.50
(82)O43760SYNGR2Synaptogyrin-20.50
(83)P05067APPAmyloid beta A4 protein0.50
(84)Q14669TRIP12E3 ubiquitin-protein ligase TRIP120.51
(85)P29317EPHA2Ephrin type-A receptor 20.51
(86)F5H8D7XRCC1DNA repair protein XRCC10.51
(87)Q9Y4B5MTCL1Microtubule cross-linking factor 10.53
(88)Q13206DDX10Probable ATP-dependent RNA helicase DDX100.54
(89)P61513RPL37A60S ribosomal protein L37a0.55
(90)Q9NW82WDR70WD repeat-containing protein 700.56
(91)P00533EGFREpidermal growth factor receptor0.56
(92)Q8N556AFAP1Actin filament-associated protein 10.56
(93)J3KNF8CYB5BCytochrome b5 type B0.56
(94)O15040TECPR2Tectonin beta-propeller repeat-containing protein 20.56
(95)O94925GLSGlutaminase kidney isoform, mitochondria0.57
(96)Q8N726CDKN2ATumor suppressor ARF0.58
(97)Q99650OSMROncostatin-M-specific receptor subunit beta0.58
(98)P07992ERCC1DNA excision repair protein ERCC-10.58
(99)O15091KIAA0391Mitochondrial ribonuclease P protein 30.60
(100)Q9NPQ8RIC8ASynembryn-A0.60
(101)Q9Y617PSAT1Phosphoserine aminotransferase0.60
(102)Q03001DSTDystonin0.61
(103)Q13751LAMB3Laminin subunit beta-30.61
(104)Q9UPQ0LIMCH1LIM and calponin homology domains-containing protein 10.61
(105)O00308WWP2NEDD4-like E3 ubiquitin-protein ligase WWP20.62
(106)P13639EEF2Elongation factor 20.63
(107)P42892ECE1Endothelin-converting enzyme 10.63
(108)Q14571ITPR2Inositol 1,4,5-trisphosphate receptor type 20.63
(109)E9PER6PDPK13-Phosphoinositide-dependent protein kinase 10.64
(110)Q92974ARHGEF2Rho guanine nucleotide exchange factor 20.65
(111)P26006ITGA3Integrin alpha-30.66
(112)Q06481APLP2Amyloid-like protein 20.66
(113)Q15050RRS1Ribosome biogenesis regulatory protein homolog0.66
(114)Q15397PUM3Pumilio homolog 30.66
(115)Q99700ATXN2Ataxin-20.66
(116)Q16706MAN2A1Alpha-mannosidase 20.67
(117)Q96HC4PDLIM5PDZ and LIM domain protein 50.67
(118)P49643PRIM2DNA primase large subunit0.67
(119)Q86YD1PTOV1Prostate tumor-overexpressed gene 1 protein0.67