Pharmacokinetic Properties of Adenosine Amine Congener in Cochlear Perilymph after Systemic Administration

Figure 2

Development of LCMS/MS methods using detection with multiple reaction monitoring (m/z 445). The retention time for ADAC is ~2.5 min. (a) ADAC calibration standard (100 ng/mL); (b) cochlear matrix; (c) cochlea spiked with ADAC (10 ng/mL); (d) perilymph matrix; (e) perilymph spiked with ADAC (10 ng/ mL). Retention time (min).

(a)

(b)

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(e)