Pharmacokinetic Properties of Adenosine Amine Congener in Cochlear Perilymph after Systemic Administration

Figure 3

Time-dependent changes in ADAC concentrations in rat cochlear perilymph after intravenous drug administration (100 μg/kg). Time-concentration data were obtained from 22 control cochleae (12 animals) exposed to ambient noise and 31 cochleae (17 animals) exposed to traumatic noise (110 dB SPL, 8–16 kHz, 2 hours). Measured ADAC concentrations (LCMS/MS) were used to plot predicted values. Pharmacokinetic properties were calculated using an Excel plugin PKSolver [17]. , extrapolated drug concentration at time 0; , elimination constant; , drug half-life in perilymph; , volume of distribution; CL, drug clearance; , area under curve (); MRT, mean residence time.