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BioMed Research International
Volume 2017, Article ID 8091462, 8 pages
https://doi.org/10.1155/2017/8091462
Research Article

Pharmacokinetic Properties of Adenosine Amine Congener in Cochlear Perilymph after Systemic Administration

1Department of Physiology and Centre for Brain Research, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
2Auckland Cancer Research Centre, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
3Department of Pharmacology, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand

Correspondence should be addressed to Srdjan M. Vlajkovic; zn.ca.dnalkcua@civokjalv.s

Received 6 October 2016; Accepted 27 November 2016; Published 18 January 2017

Academic Editor: Vickram Ramkumar

Copyright © 2017 Hao Chang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. WHO, Deafness and Hearing Loss, 2015, http://www.who.int/mediacentre/factsheets/fs300/en/.
  2. NIOSH, Occupational Noise Exposure: Revised Criteria, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA, 1998.
  3. P. R. Thorne, S. N. Ameratunga, J. Stewart et al., “Epidemiology of noise-induced hearing loss in New Zealand,” New Zealand Medical Journal, vol. 121, no. 1280, pp. 33–44, 2008. View at Google Scholar · View at Scopus
  4. D. Henderson and R. P. Hamernik, “Impulse noise: critical review,” Journal of the Acoustical Society of America, vol. 80, no. 2, pp. 569–584, 1986. View at Publisher · View at Google Scholar · View at Scopus
  5. D. Henderson, E. C. Bielefeld, K. C. Harris, and B. H. Hu, “The role of oxidative stress in noise-induced hearing loss,” Ear and Hearing, vol. 27, no. 1, pp. 1–19, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. D. Yamashita, H.-Y. Jiang, J. Schacht, and J. M. Miller, “Delayed production of free radicals following noise exposure,” Brain Research, vol. 1019, no. 1-2, pp. 201–209, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. S. G. Kujawa and M. C. Liberman, “Adding insult to injury: cochlear nerve degeneration after “temporary” noise-induced hearing loss,” Journal of Neuroscience, vol. 29, no. 45, pp. 14077–14085, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. A. C. Y. Wong, C. X. Guo, R. Gupta, G. D. Housley, P. R. Thorne, and S. M. Vlajkovic, “Post exposure administration of A1 adenosine receptor agonists attenuates noise-induced hearing loss,” Hearing Research, vol. 260, no. 1-2, pp. 81–88, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. N. Gunewardene, C. X. Guo, A. C. Y. Wong, P. R. Thorne, and S. M. Vlajkovic, “Adenosine amine congener ameliorates cisplatin-induced hearing loss,” World Journal of Otorhinolaryngology, vol. 3, no. 3, pp. 100–107, 2013. View at Publisher · View at Google Scholar
  10. S. M. Vlajkovic, K.-H. Lee, A. C. Y. Wong et al., “Adenosine amine congener mitigates noise-induced cochlear injury,” Purinergic Signalling, vol. 6, no. 2, pp. 273–281, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. S. M. Vlajkovic, H. Chang, S. Y. Paek et al., “Adenosine amine congener as a cochlear rescue agent,” BioMed Research International, vol. 2014, Article ID 841489, 10 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  12. T. Kaur, V. Borse, S. Sheth et al., “Adenosine A1 receptor protects against cisplatin ototoxicity by suppressing the NOX3/STAT1 inflammatory pathway in the cochlea,” Journal of Neuroscience, vol. 36, no. 14, pp. 3962–3977, 2016. View at Publisher · View at Google Scholar · View at Scopus
  13. S. H. Snyder, “Adenosine as a neuromodulator,” Annual Review of Neuroscience, vol. 8, pp. 103–124, 1985. View at Publisher · View at Google Scholar · View at Scopus
  14. B. B. Fredholm, “Adenosine, an endogenous distress signal, modulates tissue damage and repair,” Cell Death and Differentiation, vol. 14, no. 7, pp. 1315–1323, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. J. Linden, “Adenosine in tissue protection and tissue regeneration,” Molecular Pharmacology, vol. 67, no. 5, pp. 1385–1387, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. T. H. Adair, “Growth regulation of the vascular system: an emerging role for adenosine,” American Journal of Physiology—Regulatory Integrative and Comparative Physiology, vol. 289, no. 2, pp. R283–R296, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. Y. Zhang, M. Huo, J. Zhou, and S. Xie, “PKSolver: an add-in program for pharmacokinetic and pharmacodynamic data analysis in Microsoft Excel,” Computer Methods and Programs in Biomedicine, vol. 99, no. 3, pp. 306–314, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. M. S. Ford, S. B. Maggirwar, L. P. Rybak, C. Whitworth, and V. Ramkumar, “Expression and function of adenosine receptors in the chinchilla cochlea,” Hearing Research, vol. 105, no. 1-2, pp. 130–140, 1997. View at Publisher · View at Google Scholar · View at Scopus
  19. S. M. Vlajkovic, S. Abi, C. J. H. Wang, G. D. Housley, and P. R. Thorne, “Differential distribution of adenosine receptors in rat cochlea,” Cell and Tissue Research, vol. 328, no. 3, pp. 461–471, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. B. H. Hu, X. Y. Zheng, S. L. McFadden, R. D. Kopke, and D. Henderson, “R-phenylisopropyladenosine attenuates noise-induced hearing loss in the chinchilla,” Hearing Research, vol. 113, no. 1-2, pp. 198–206, 1997. View at Publisher · View at Google Scholar · View at Scopus
  21. N. G. Hight, S. L. McFadden, D. Henderson, R. F. Burkard, and T. Nicotera, “Noise-induced hearing loss in chinchillas pre-treated with glutathione monoethylester and R-PIA,” Hearing Research, vol. 179, no. 1-2, pp. 21–32, 2003. View at Publisher · View at Google Scholar · View at Scopus
  22. K. A. Jacobson, K. L. Kirk, W. L. Padgett, and J. W. Daly, “Functionalized congeners of adenosine: preparation of analogues with high affinity for A1-adenosine receptors,” Journal of Medicinal Chemistry, vol. 28, no. 9, pp. 1341–1346, 1985. View at Publisher · View at Google Scholar · View at Scopus
  23. D. K. J. E. Von Lubitz, R. C.-S. Lin, I. A. Paul et al., “Postischemic administration of adenosine amine congener (ADAC): analysis of recovery in gerbils,” European Journal of Pharmacology, vol. 316, no. 2-3, pp. 171–179, 1996. View at Publisher · View at Google Scholar · View at Scopus
  24. D. K. J. E. Von Lubitz, R. C.-S. Lin, N. Bischofberger et al., “Protection against ischemic damage by adenosine amine congener, a potent and selective adenosine A1 receptor agonist,” European Journal of Pharmacology, vol. 369, no. 3, pp. 313–317, 1999. View at Publisher · View at Google Scholar · View at Scopus
  25. D. Blum, D. Gall, M.-C. Galas, P. D'Alcantara, K. Bantubungi, and S. N. Schiffmann, “The adenosine A1 receptor agonist adenosine amine congener exerts a neuroprotective effect against the development of striatal lesions and motor impairments in the 3-nitropropionic acid model of neurotoxicity,” Journal of Neuroscience, vol. 22, no. 20, pp. 9122–9133, 2002. View at Google Scholar · View at Scopus
  26. L. J. Langman and C. L. H. Snozek, LC-MS in Drug Analysis: Methods and Protocols, Humana Press, New York, NY, USA, 1st edition, 2012.
  27. L. J. Jolivette and K. W. Ward, “Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: molecular properties associated with extrapolative success or failure,” Journal of Pharmaceutical Sciences, vol. 94, no. 7, pp. 1467–1483, 2005. View at Publisher · View at Google Scholar · View at Scopus
  28. M. Thorne, A. N. Salt, J. E. DeMott, M. M. Henson, O. W. Henson Jr., and S. L. Gewalt, “Cochlear fluid space dimensions for six species derived from reconstructions of three-dimensional magnetic resonance images,” Laryngoscope, vol. 109, no. 10, pp. 1661–1668, 1999. View at Publisher · View at Google Scholar · View at Scopus
  29. US Department of Health and Human Services FDA, Guidance for Industry: Bioanalytical Method Validation, Center for Drug Evaluation and Research (CDER) and Center for Veterinary Medicine (CVM), 2001.
  30. H. Chang, R. S. Telang, P. R. Thorne, and S. M. Vlajkovic, “The pharmacokinetics of adenosine amine congener (ADAC) in plasma and inner ear,” in Proceedings of the 31st Australasian Winter Conference on Brain Research, p. 60, Queenstown, NZ, USA, August 2013.
  31. K. A. Jacobson and Z.-G. Gao, “Adenosine receptors as therapeutic targets,” Nature Reviews Drug Discovery, vol. 5, no. 3, pp. 247–264, 2006. View at Publisher · View at Google Scholar · View at Scopus
  32. A. N. Salt, S. A. Hale, and S. K. R. Plonkte, “Perilymph sampling from the cochlear apex: a reliable method to obtain higher purity perilymph samples from scala tympani,” Journal of Neuroscience Methods, vol. 153, no. 1, pp. 121–129, 2006. View at Publisher · View at Google Scholar · View at Scopus
  33. M. E. Hoffer, K. Allen, R. D. Kopke, P. Weisskopf, K. Gottshall, and D. Wester, “Transtympanic versus sustained-release administration of gentamicin: kinetics, morphology, and function,” Laryngoscope, vol. 111, no. 8, pp. 1343–1357, 2001. View at Publisher · View at Google Scholar · View at Scopus
  34. W. Arnold, P. Senn, M. Hennig et al., “Novel slow- and fast-type drug release round-window microimplants for local drug application to the cochlea: an experimental study in guinea pigs,” Audiology and Neuro-Otology, vol. 10, no. 1, pp. 53–63, 2005. View at Publisher · View at Google Scholar · View at Scopus
  35. T. Mom, J. Chazal, J. Gabrillargues, L. Gilain, and P. Avan, “Cochlear blood supply: an update on anatomy and function,” ORL France, vol. 88, pp. 81–88, 2005. View at Google Scholar
  36. K. Hirose, J. J. Hartsock, S. Johnson, P. Santi, and A. N. Salt, “Systemic lipopolysaccharide compromises the blood-labyrinth barrier and increases entry of serum fluorescein into the perilymph,” Journal of the Association for Research in Otolaryngology, vol. 15, no. 5, pp. 707–719, 2014. View at Publisher · View at Google Scholar · View at Scopus
  37. S. K. Juhn, B. A. Hunter, and R. M. Odland, “Blood-labyrinth barrier and fluid dynamics of the inner ear,” International Tinnitus Journal, vol. 7, no. 2, pp. 72–83, 2001. View at Google Scholar · View at Scopus
  38. M. Suzuki, T. Yamasoba, and K. Kaga, “Development of the blood-labyrinth barrier in the rat,” Hearing Research, vol. 116, no. 1-2, pp. 107–112, 1998. View at Publisher · View at Google Scholar · View at Scopus
  39. M. Suzuki, T. Yamasoba, T. Ishibashi, J. M. Miller, and K. Kaga, “Effect of noise exposure on blood-labyrinth barrier in guinea pigs,” Hearing Research, vol. 164, no. 1-2, pp. 12–18, 2002. View at Publisher · View at Google Scholar · View at Scopus
  40. M. Tagaya, M. Yamazaki, M. Teranishi et al., “Endolymphatic hydrops and blood–labyrinth barrier in Ménière's disease,” Acta Oto-Laryngologica, vol. 131, no. 5, pp. 474–479, 2011. View at Publisher · View at Google Scholar · View at Scopus
  41. X. Li, X. Shi, Y. Qiao et al., “Observation of permeability of blood-labyrinth barrier during cytomegalovirus-induced hearing loss,” International Journal of Pediatric Otorhinolaryngology, vol. 78, no. 7, pp. 995–999, 2014. View at Publisher · View at Google Scholar · View at Scopus
  42. Y.-X. Wu, G.-X. Zhu, X.-Q. Liu et al., “Noise alters guinea pig's blood-labyrinth barrier ultrastructure and permeability along with a decrease of cochlear Claudin-5 and Occludin,” BMC Neuroscience, vol. 15, article 136, 2014. View at Publisher · View at Google Scholar · View at Scopus
  43. X. Shi, “Physiopathology of the cochlear microcirculation,” Hearing Research, vol. 282, no. 1-2, pp. 10–24, 2011. View at Publisher · View at Google Scholar · View at Scopus
  44. E.-I. Lepist, V. L. Damaraju, J. Zhang et al., “Transport of A1 adenosine receptor agonist tecadenoson by human and mouse nucleoside transporters: evidence for blood-brain barrier transport by murine equilibrative nucleoside transporter 1 mENT1,” Drug Metabolism and Disposition, vol. 41, no. 4, pp. 916–922, 2013. View at Publisher · View at Google Scholar · View at Scopus
  45. S. M. Vlajkovic, G. D. Housley, and P. R. Thorne, “Adenosine and the auditory system,” Current Neuropharmacology, vol. 7, no. 3, pp. 246–256, 2009. View at Publisher · View at Google Scholar · View at Scopus