Collagen Sponge Functionalized with Chimeric Anti-BMP-2 Monoclonal Antibody Mediates Repair of Critical-Size Mandibular Continuity Defects in a Nonhuman Primate Model

<div>Representative 2D and 3D reconstructed CBCT images of mandibular continuity defects of experimental and control groups at 6 and 12 weeks postsurgically. 3D reconstructed CBCT images illustrate the landmarks used for axial plane sections for 2D image analysis. Accordingly, axial sections were obtained at equal distances from the superior region of the mandibular defects, above titanium plates (superior plane), as well as at middle (middle plane) and inferior regions (inferior plane) of the mandible. Representative 2D and 3D reconstructed images of defects treated with isotype-matched control mAb (a, b) or chimeric anti-BMP-2 mAb (c, d) at 6 (a, c) and 12 (b, d) time points are illustrated.</div>

BioMed Research International

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Figure 2: Collagen Sponge Functionalized with Chimeric Anti-BMP-2 Monoclonal Antibody Mediates Repair of Critical-Size Mandibular Continuity Defects in a Nonhuman Primate Model 

Figure 2 | Collagen Sponge Functionalized with Chimeric Anti-BMP-2 Monoclonal Antibody Mediates Repair of Critical-Size Mandibular Continuity Defects in a Nonhuman Primate Model 