Collagen Sponge Functionalized with Chimeric Anti-BMP-2 Monoclonal Antibody Mediates Repair of Critical-Size Mandibular Continuity Defects in a Nonhuman Primate Model

Figure 4

3D analysis of bone volume within surgical defect. Mandibular continuity defects were treated with chimeric anti-BMP-2 mAb compared to isotype-matched control mAb. CBCT images taken at 6 and 12 weeks postsurgically and the volume of bone within the defect sites at two time points was quantified (a). Quantitative analysis of bone volume (mm³) within defects treated with chimeric anti-BMP-2 mAb or isotype-matched control mAb (b). Significantly higher bone volume was detected within defects treated with chimeric anti-BMP-2 mAb compared to isotype-matched control mAb at both time points ().

(a)

(b)