Review of Natural Product-Derived Compounds as Potent Antiglioblastoma Drugs

Table 2

ROS generation of natural products.

Family names	Medical plants	Compounds/extracts	Dose/duration	Target molecules and additional efficacy	Cell lines	References
Zygophyllaceae	Balanites aegyptiaca	Balanitin-6 (28%), balanitin-7 (72%)	830 nM for 24, 48, 72 h	↓ATP (disorganization of actin cytoskeleton)	U373	[76]
		Obtusaquinone	(In vitro); 5 µM for 24 h (in vivo); 7.5 mg/kg for 21 days	↑ROS, p53, caspase 3/7; ERK pathway	Gli36, U87 MG, U251, GBM8, GBM11/5, VU147	[77]
Clusiaceae	Garcinia mangostana	γ-Mangostin	80 μM for 8 h	↑NK cell, ROS; ↓PGE2, COX-2, NO,	U87 MG, GBM 8401	[39]
N/A	Brazilian propolis (Pro) (not specific plant)	[Homocysteine (Hcy)] to provoke cognitive dysfunction	100 μM DL-Hcy + 0, 0.2, 0.4, 0.8, 1.6, 3.2 μg/mL for 72 h (intracellular ROS detection); (after age 12 weeks mice + 1 week adaption) 0% Pro + Hcy(x), 0% Pro + Hcy(o), 0.25% Pro + Hcy(o), 0.05% Pro + Hcy(o) for 5, 14, 27 week (animal experiment); 0, 100 μM Hcy + 0, 0.27, 1.38 μg/mL Pro (final concentration each) for 0, 7, 11, 14, 17, 21, 24 days	↑relative fluorescence intensity; ↓relative ROS intensity, in vivo Plasma Hcy concentrations, in vitro amyloids formation; Propolis intake made rats recovered from Hcy induced cognitive dysfunction	Neuroblastoma SH-SY5Y, glioblastoma U-251MG	[78]