Review Article
Review of Natural Product-Derived Compounds as Potent Antiglioblastoma Drugs
Table 3
Antiangiogenesis effect of natural products.
| Family names | Medical plants | Compounds/extracts | Dose/duration | Target molecules and additional efficacy | Cell lines | References |
| Araliaceae | Panax ginseng | Ginsenoside Rg3 | 0–180 μg/ml for 72 h (in vitro) 10 mg/kg/day for 8 days (in vivo) | ↓VEGF, Bcl-2 (HUVEC mRNA), VEGFA, MVD Inhibit HUVEC proliferation, less increase rCBV | Rat C6 glioma cells | [68] |
| Zingiberaceae | Curcuma amada | Supercritical CO2 extract | 0–100 μg/ml for 72 h 0–20 μg/ml for 24 h | ↓VEGF mRNA, VEGF | U87MG | [79] |
| Vitaceae | Vitis vinifera | Red grape skin polyphenolic extract | 0–25 μg/ml for 24 h | ↓tube network formation, VEGF, S1P, ERK, p38/MAPK phosphorylation, S1P-induced PAF synthesis | U87MG | [80] |
| Cannabaceae | Cannabis sativa | Δ9-Tetrahydrocannabinol, cannabidiol | 7.5 mg/kg/day for 22 days | ↓tumor vascularization (CD31 immunostaining) | U87MG | [28] |
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