| | Family names | Medical plants | Compounds/extracts | Dose/duration | Target molecules and additional efficacy | Cell lines | References |
| | Theaceae | Camelliasinensis (green tea) | Vitamin C (as ascorbic acid and as Mg, Ca, and palmitate ascorbate) 700 mg; L-lysine 1000 mg; L-proline 750 mg; L-arginine 500 mg; N-acetyl cysteine 200 mg; standardized green tea extract (80% polyphenol) 1000 mg; selenium 30 μg; copper 2 mg; manganese 1 mg | 0–1000 μg/ml | ↑TIMP-2
↓MMP-2, MMP-9, uPA | LN-18, T-98G, A-172 | [81] |
| | Theaceae | Camellia sinensis | Epigallocatechin gallate (EGCG) | 50–500 μg/ml | ↓-2, MMP-9 | T-98G | [82] |
| | Sargassaceae | Sargassum serratifolium | Hexane, ethanol, ethyl extract | 5–15 μg/ml
for 12–24 h | ↓ MMP-2, MMP-9, C-Raf, MEK, ERK, phospho-ERK, wound area, invasive cells | U87MG | [84] |
| | Apiaceae | Cnidium monnieri | Osthole | 20–80 μM
for 24 h | ↓MMP-2, MMP–9
Inhibit IGF-1-induced EMT | GBM8401 | [85] |
| | | Peanuts, grapes, red wine | Resveratrol | 5–20 μM
for 48 h | ↓MMP-2, NF-κB pathway, PI3K/AKT signaling pathway | Glioblastoma-initiating cells (GICs) | [86] |
| | | Flavonoids (plants, herbs, fruits) | Quercetin (QE), baicalein (BE), myricetin (ME) | 0–50 μM
for 30 min | ↓ ERK-activated COX-2/PGE2, MMP-9 | U87MG | [83] |
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