Review of Natural Product-Derived Compounds as Potent Antiglioblastoma Drugs

Table 6

Multidrug resistance and natural products.

Family names	Medical plants	Compounds/extracts	Dose/duration	Target molecules and additional efficacy	Cell lines	References
Solanaceae	Withania somnifera	Withaferin A	2.5 μM, 1 μM for 24 h	↑ERK1/2, HSP32, HSP70; AKT, mTOR, p70 S6K, c-Met, EGFR, ↓Her2, HSF1; Oxidative stress, heat shock response, AKT/mTOR pathway, MGMT	U87, U251, T98G	[57]
Zingiberaceae	Aframomum arundinaceum	Methanol extract	40 μg/mL for 72 h	Collateral sensitivity (hypersensitivity)	U87MG.ΔEGFR	[90]
Clusiaceae	Garcinia nobilis	8-Hydroxycudra-xanthone G, cudraxanthone I	22.49 μM for 24 h	Collateral sensitivity (hypersensitivity)	U87MG	[91]
Moraceae	Dorstenia barteri	Isobavachalcone	23.78 μM for 24 h	Collateral sensitivity (hypersensitivity)	U87MG	[90]